Please use this identifier to cite or link to this item:
Title: Hepatitis C recurrence: the Achilles heel of liver transplantation.
Austin Authors: Howell, Jessica;Angus, Peter W ;Gow, Paul J 
Affiliation: Department of Medicine, University of Melbourne, Melbourne, Australia
Liver Transplant Unit, Austin Hospital, Melbourne, Australia
Issue Date: 30-Dec-2013
Publication information: Transplant Infectious Disease : An Official Journal of the Transplantation Society 2013; 16(1): 1-16
Abstract: Hepatitis C virus (HCV) infection is the most common indication for liver transplantation worldwide; however, recurrence post transplant is almost universal and follows an accelerated course. Around 30% of patients develop aggressive HCV recurrence, leading to rapid fibrosis progression (RFP) and culminating in liver failure and either death or retransplantation. Despite many advances in our knowledge of clinical risks for HCV RFP, we are still unable to accurately predict those most at risk of adverse outcomes, and no clear consensus exists on the best approach to management. This review presents a critical overview of clinical factors shown to influence the course of HCV recurrence post transplant, with particular focus on recent data identifying the important role of metabolic factors, such as insulin resistance, in HCV recurrence. Emerging data for genetic markers of HCV recurrence and their usefulness for predicting adverse outcomes will also be explored.
Gov't Doc #: 24372756
DOI: 10.1111/tid.12173
Type: Journal Article
Subjects: diabetes
hepatitis C
liver fibrosis
living donor transplantation
metabolic syndrome
viral hepatitis
Age Factors
Diabetes Mellitus
Disease Progression
Hepatitis C, Chronic
Insulin Resistance
Liver Cirrhosis
Liver Failure
Liver Transplantation
Living Donors
Metabolic Syndrome X
Reoperation.statistics & numerical data
Reperfusion Injury
Risk Factors
Warm Ischemia
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Nov 25, 2022

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.