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Title: Low physical activity levels and functional decline in individuals with lung cancer.
Austin Authors: Granger, Catherine L ;McDonald, Christine F ;Irving, Louis;Clark, Ross A;Gough, Karla;Murnane, Andrew;Mileshkin, Linda;Krishnasamy, Meinir;Denehy, Linda
Affiliation: Department of Physiotherapy, The University of Melbourne, Level 7, Alan Gilbert Building, Parkville, Victoria 3010, Australia
Department of Respiratory and Sleep Medicine, Royal Melbourne Hospital, Parkville, Victoria 3010, Australia
Department of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australia
Department of Cancer Experiences Research, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
Institute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 26-Nov-2013
Publication information: Lung Cancer (amsterdam, Netherlands) 2013; 83(2): 292-9
Abstract: Physical activity has been infrequently measured objectively in non-small cell lung cancer (NSCLC). We aimed to investigate levels of physical activity, functional and patient reported outcomes at diagnosis and over six months in participants with recently diagnosed NSCLC and compare results with both physical activity guidelines and outcomes of similar-aged healthy individuals.This prospective observational study assessed 50 individuals from three Australian tertiary hospitals with stage I-IIIB NSCLC at diagnosis, then 10 weeks and six months later. Thirty five healthy individuals without cancer were assessed once. Outcome measures included tri-axial accelerometery (number of steps per day), six minute walk distance (6MWD), muscle strength and questionnaires including health-related quality of life (HRQoL).Individuals with NSCLC were engaged in significantly less physical activity than similar-aged healthy individuals, with 60% not meeting physical activity guidelines. At diagnosis they had worse quadriceps strength, nutritional status and HRQoL. Over six months, participants with NSCLC experienced decline in self-reported physical activity, 6MWD and muscle strength, and worsening symptoms.At diagnosis individuals with NSCLC engage in less physical activity, are weaker and more depressed than healthy individuals and their self-reported physical activity declines over six months. Future studies are required to investigate the efficacy of interventions to increase physical activity.
Gov't Doc #: 24360323
DOI: 10.1016/j.lungcan.2013.11.014
Type: Journal Article
Subjects: Accelerometery
Functional decline
Health-related quality of life
Lung cancer
Physical activity
Carcinoma, Non-Small-Cell Lung.physiopathology
Follow-Up Studies
Lung Neoplasms.physiopathology
Middle Aged
Motor Activity
Muscle Strength
Neoplasm Staging
Prospective Studies
Quality of Life
Self Report
Appears in Collections:Journal articles

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