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Title: Preoperative urinary neutrophil gelatinase-associated lipocalin and outcome in high-risk heart failure patients undergoing cardiac surgery.
Austin Authors: Silvetti, Simona;Meroni, Roberta;Bignami, Elena;Bove, Tiziana;Landoni, Giovanni;Zangrillo, Alberto;Bellomo, Rinaldo ;Pappalardo, Federico
Affiliation: Departments of Intensive Care and Cardiac Surgery, Austin Health, Melbourne, Australia
Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milano, Italy.
Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milano, Italy
Issue Date: 2-Dec-2013
Publication information: Journal of Cardiothoracic and Vascular Anesthesia 2013; 28(2): 323-7
Abstract: To investigate the ability of early urinary neutrophil gelatinase-associated lipocalin to predict postoperative complications in adult patients with ventricular dysfunction undergoing cardiac surgery.Prospective observational study.Single-center study, university hospital.Fifty-six adult high-risk cardiac surgical patients with preoperative cardiac failure.None.Demographic and clinical characteristics were obtained, and neutrophil gelatinase-associated lipocalin was measured at baseline and at several time points after surgery. Patient characteristics and neutrophil gelatinase-associated lipocalin levels were related to renal and patient outcome. On multivariate analyses, preoperative urinary neutrophil gelatinase-associated lipocalin was an independent predictor of length of intensive care stay (p = 0.004) and in-hospital stay (p = 0.04), but not of acute kidney injury or renal replacement therapy and was not associated with baseline renal function.In a cohort of high-risk cardiac surgery patients, preoperative urinary neutrophil gelatinase-associated lipocalin value provided prognostic information that was independent of the onset of acute kidney injury or of preoperative renal function.
Gov't Doc #: 24295718
DOI: 10.1053/j.jvca.2013.07.007
Journal: Journal of Cardiothoracic and Vascular Anesthesia
Type: Journal Article
Subjects: acute kidney injury
cardiac surgery
intensive care
neutrophil gelatinase-associated lipocalin
Acute Kidney Injury.urine
Acute-Phase Proteins.urine
Aged, 80 and over
Biological Markers.urine
Cardiac Output, Low.etiology
Cardiac Surgical Procedures.methods
Cardiotonic Agents.therapeutic use
Intensive Care
Intra-Aortic Balloon Pumping
Kidney Function Tests
Length of Stay
Linear Models
Middle Aged
Predictive Value of Tests
Proto-Oncogene Proteins.urine
Renal Replacement Therapy
Risk Assessment
Treatment Outcome
Appears in Collections:Journal articles

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