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Title: Optimal conditions required for influenza A infection-enhanced cross-priming of CD8⁺ T cells specific to cell-associated antigens.
Austin Authors: Wei, Joe;Waithman, Jason;Xiao, Kun;Oveissi, Sara;Chen, Weisan
Affiliation: Ludwig Institute for Cancer Research, Melbourne-Austin Branch, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 10-Sep-2013
Publication information: Immunology and Cell Biology 2013; 91(9): 576-82
Abstract: Dendritic cells can take up exogenous tumor antigens and present their antigenic epitopes to CD8⁺ T cells (T(CD8⁺)), a process called cross-presentation. Cross-presentation is especially important in antitumor immunity because tumor cells, although carrying tumor antigens, do not activate naive T cells efficiently because of a lack of co-stimulatory molecules. Our group has recently shown that influenza A virus (IAV) infection of allogeneic cells lead to enhanced cross-priming of T(CD8⁺) specific to cellular antigens. To develop this into a potential vaccine strategy, in this study, we have systematically investigated the numbers of allogeneic cells infected by IAV, IAV doses and their infectious activity, the length of in vitro infection and other associated factors. We have defined the optimal immune-enhancing conditions and we have also shown in vivo that such enhanced cross-priming did lead to enhanced tumor protection. The knowledge should be useful for developing more robust cancer vaccine.
Gov't Doc #: 24018533
DOI: 10.1038/icb.2013.46
Journal: Immunology and cell biology
Type: Journal Article
Subjects: Animals
Antigens, Neoplasm.immunology
Bystander Effect.immunology
CD8-Positive T-Lymphocytes.immunology
Cancer Vaccines
Cells, Cultured
Dendritic Cells.immunology.virology
Influenza A virus.immunology.pathogenicity
Melanoma, Experimental.immunology.therapy
Membrane Proteins.immunology
Mice, Inbred C57BL
Neoplasm Transplantation
Orthomyxoviridae Infections.immunology
Appears in Collections:Journal articles

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