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Title: Nodular heterotopia and absence seizures: fMRI evidence that they may be connected.
Austin Authors: Carney, Patrick W ;Masterton, Richard A J;Gill, Deepak S;Jackson, Graeme D 
Affiliation: Brain Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria 3084, Australia
Epilepsy Research Centre, Department of Medicine, University of Melbourne, Heidelberg, Victoria 3084, Australia
Austin Health, Heidelberg, Victoria 3081, Australia
Issue Date: 6-Aug-2013
Publication information: Epilepsy Research 2013; 106(3): 451-5
Abstract: In this study we used EEG-fMRI to investigate whether peri-ventricular nodular heterotopia (PNH) are connected to the seizure generating network in individuals initially diagnosed with absence seizures (AS) who were later found to have co-existent PNH. We performed event related EEG-fMRI of the patients typical events as well as performing functional connectivity (FC) seeded from the PNH to answer this question. Both subjects demonstrated event related BOLD change in the "core" absence network. Subject 1 also displayed event related BOLD increase in the nodules while FC analysis demonstrated connectivity between the nodules and the thalami and striatum bilaterally. The second subject did not display event related BOLD in the PNH but FC analysis demonstrated strong connections between the PNH and the parietal cortex. This study demonstrates that the peri-ventricular nodules can show connectivity to the absence network in individuals with AS and may be involved in seizure generation.
Gov't Doc #: 23992952
DOI: 10.1016/j.eplepsyres.2013.07.005
Journal: Epilepsy research
Type: Journal Article
Subjects: Absence seizures
Functional neuroimaging
Nodular heterotopia
Cohort Studies
Epilepsy, Absence.complications.pathology
Epilepsy, Generalized.complications.pathology
Evoked Potentials
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Myoclonic Epilepsy, Juvenile.complications.pathology
Parietal Lobe.pathology
Periventricular Nodular Heterotopia.complications.pathology
Young Adult
Appears in Collections:Journal articles

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