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Title: Community-onset Staphylococcus aureus infections presenting to general practices in South-eastern Australia.
Austin Authors: Bennett, Catherine M;Coombs, Geoffrey W;Wood, G M;Howden, Benjamin P ;Johnson, L E A;White, D;Johnson, Paul D R 
Affiliation: The University of Melbourne, Melbourne, Australia
Austin Health, Melbourne, Australia
Department of Microbiology and Infectious Diseases, PathWest Laboratory Medicine-WA, Royal Perth Hospital, Australia
Issue Date: 18-Jul-2013
Publication information: Epidemiology and Infection 2013; 142(3): 501-11
Abstract: Community-acquired Staphylococcus aureus infections are a public health concern, yet little is known about infections that do not present to hospital. We identified community-onset S. aureus infections via specimens submitted to a community-based pathology service. Referring doctors confirmed eligibility and described infection site, severity and treatment. Isolates were characterized on antibiotic resistance, PFGE, MLST/SCCmec, and Panton-Valentine leukocidin (PVL), representing 106 community-onset infections; 34 non-multiresistant methicillin-resistant S. aureus (nmMRSA) (resistant to <3 non-β-lactam antibiotics), 15 multiply antibiotic-resistant MRSA (mMRSA) and 57 methicillin-sensitive S. aureus (MSSA). Most (93%) were skin and soft tissue infections. PVL genes were carried by 42% of nmMRSA isolates [95% confidence interval (CI) 26-61] and 15% of MSSA (95% CI 8-28). PVL was associated with infections of the trunk, head or neck (56·4% vs. 24·3%, P=0·005) in younger patients (23 vs. 52 years, P<0·001), and with boils or abscesses (OR 8·67, 95% CI 2·9-26·2), suggesting underlying differences in exposure and/or pathogenesis.
Gov't Doc #: 23866772
DOI: 10.1017/S0950268813001581
Type: Journal Article
Subjects: Adult
Anti-Bacterial Agents.pharmacology
Community-Acquired Infections.drug therapy.epidemiology.microbiology
Drug Resistance, Bacterial
Methicillin-Resistant Staphylococcus aureus.isolation & purification.pathogenicity
Middle Aged
Polymerase Chain Reaction
Severity of Illness Index
Staphylococcal Infections.drug therapy.epidemiology.microbiology
Staphylococcus aureus.isolation & purification.pathogenicity
Appears in Collections:Journal articles

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