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Title: Tumor-specific T-cell help is associated with improved survival in melanoma.
Austin Authors: Woods, Katherine;Cebon, Jonathan S 
Affiliation: Ludwig Institute for Cancer Research Melbourne-Austin Branch, Heidelberg, Australia
Issue Date: 17-Jul-2013
Publication information: Clinical Cancer Research 2013; 19(15): 4021-3
Abstract: Despite success with immune checkpoint inhibitors, clinical benefit from cancer vaccines remains elusive. Combined targeting of melanoma-specific CD4(+) and CD8(+) T-lymphocyte epitopes was associated with improved survival compared with targeting either alone, or when a nonspecific helper epitope was used. We discuss the potential role of antigen-specific CD4 help.
Gov't Doc #: 23864163
DOI: 10.1158/1078-0432.CCR-13-1349
Type: Journal Article
Subjects: Antigens, CD4.immunology
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cancer Vaccines.immunology.therapeutic use
Epitopes, T-Lymphocyte.immunology
Flow Cytometry
Lymphocyte Activation.immunology
Survival Analysis
Appears in Collections:Journal articles

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