Austin Health

Title
Tumor-specific T-cell help is associated with improved survival in melanoma.
Publication Date
2013-07-17
Author(s)
Woods, Katherine
Cebon, Jonathan S
Type of document
Journal Article
DOI
10.1158/1078-0432.CCR-13-1349
Abstract
Despite success with immune checkpoint inhibitors, clinical benefit from cancer vaccines remains elusive. Combined targeting of melanoma-specific CD4(+) and CD8(+) T-lymphocyte epitopes was associated with improved survival compared with targeting either alone, or when a nonspecific helper epitope was used. We discuss the potential role of antigen-specific CD4 help.
Link
link
Citation
Clinical Cancer Research 2013; 19(15): 4021-3
Jornal Title
Clinical Cancer Research

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