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https://ahro.austin.org.au/austinjspui/handle/1/11812| Title: | Tumor-specific T-cell help is associated with improved survival in melanoma. | Austin Authors: | Woods, Katherine;Cebon, Jonathan S | Affiliation: | Ludwig Institute for Cancer Research Melbourne-Austin Branch, Heidelberg, Australia | Issue Date: | 17-Jul-2013 | Publication information: | Clinical Cancer Research 2013; 19(15): 4021-3 | Abstract: | Despite success with immune checkpoint inhibitors, clinical benefit from cancer vaccines remains elusive. Combined targeting of melanoma-specific CD4(+) and CD8(+) T-lymphocyte epitopes was associated with improved survival compared with targeting either alone, or when a nonspecific helper epitope was used. We discuss the potential role of antigen-specific CD4 help. | Gov't Doc #: | 23864163 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/11812 | DOI: | 10.1158/1078-0432.CCR-13-1349 | Journal: | Clinical Cancer Research | URL: | https://pubmed.ncbi.nlm.nih.gov/23864163 | Type: | Journal Article | Subjects: | Antigens, CD4.immunology CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Cancer Vaccines.immunology.therapeutic use Epitopes, T-Lymphocyte.immunology Flow Cytometry Humans Immunotherapy Lymphocyte Activation.immunology Melanoma.immunology.pathology.therapy Survival Analysis |
| Appears in Collections: | Journal articles |
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