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Title: Population genetics and the evolution of virulence in Staphylococcus aureus.
Austin Authors: Chua, Kyra Y L ;Howden, Benjamin P ;Jiang, Jhih-Hang;Stinear, Timothy P;Peleg, Anton Y
Affiliation: Department of Infectious Diseases, The Alfred Hospital, Melbourne, Victoria 3181, Australia
Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA
Infectious Diseases
Department of Microbiology and Immunology, University of Melbourne, Victoria 3052, Australia
Issue Date: 27-Apr-2013
Publication information: Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases 2013; 21(): 554-62
Abstract: Staphylococcus aureus is one of the most important human pathogens, causing life-threatening infection in the community and hospital setting. The population genetics of S. aureus and the evolution of virulence is the focus of this review. We describe the various techniques in determining S. aureus population structure and discuss the insights gained from whole genome sequencing of various S. aureus strains. The emergence of community-acquired, methicillin-resistant S. aureus provides a framework for the discussion on evolution of virulence, and the role of horizontal gene transfer in the development of virulence and antibiotic resistance is explored. The knowledge generated from population genetics has the potential to inform strategies to assist in the prevention or treatment of this highly successful human pathogen.
DOI: 10.1016/j.meegid.2013.04.026
Journal: Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Type: Journal Article
Subjects: Methicillin-resistant S. aureus
Molecular epidemiology
Multi-locus sequence typing
S. aureus
Drug Resistance, Bacterial
Evolution, Molecular
Gene Transfer, Horizontal
Genome, Bacterial
Molecular Typing
Sequence Analysis, DNA
Staphylococcal Infections.microbiology
Staphylococcus aureus.classification.genetics.isolation & purification.pathogenicity
Virulence Factors.genetics.metabolism
Appears in Collections:Journal articles

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