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https://ahro.austin.org.au/austinjspui/handle/1/11753| Title: | Population genetics and the evolution of virulence in Staphylococcus aureus. | Austin Authors: | Chua, Kyra Y L ;Howden, Benjamin P ;Jiang, Jhih-Hang;Stinear, Timothy P;Peleg, Anton Y | Affiliation: | Department of Infectious Diseases, The Alfred Hospital, Melbourne, Victoria 3181, Australia Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA Infectious Diseases Department of Microbiology and Immunology, University of Melbourne, Victoria 3052, Australia Microbiology |
Issue Date: | 27-Apr-2013 | Publication information: | Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases 2013; 21(): 554-62 | Abstract: | Staphylococcus aureus is one of the most important human pathogens, causing life-threatening infection in the community and hospital setting. The population genetics of S. aureus and the evolution of virulence is the focus of this review. We describe the various techniques in determining S. aureus population structure and discuss the insights gained from whole genome sequencing of various S. aureus strains. The emergence of community-acquired, methicillin-resistant S. aureus provides a framework for the discussion on evolution of virulence, and the role of horizontal gene transfer in the development of virulence and antibiotic resistance is explored. The knowledge generated from population genetics has the potential to inform strategies to assist in the prevention or treatment of this highly successful human pathogen. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/11753 | DOI: | 10.1016/j.meegid.2013.04.026 | ORCID: | Journal: | Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases | URL: | https://pubmed.ncbi.nlm.nih.gov/23628638 | Type: | Journal Article | Subjects: | Methicillin-resistant S. aureus Molecular epidemiology Multi-locus sequence typing S. aureus Drug Resistance, Bacterial Evolution, Molecular Gene Transfer, Horizontal Genome, Bacterial Humans Molecular Typing Sequence Analysis, DNA Staphylococcal Infections.microbiology Staphylococcus aureus.classification.genetics.isolation & purification.pathogenicity Virulence Factors.genetics.metabolism |
| Appears in Collections: | Journal articles |
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