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Title: Cognitive changes after saline or plasmalyte infusion in healthy volunteers: a multiple blinded, randomized, cross-over trial.
Austin Authors: Story, David A ;Lees, Lucy;Weinberg, Laurence ;Teoh, Soon-Yee;Lee, Katherine J;Velissaris, Sarah;Bellomo, Rinaldo ;Wilson, Sarah J
Affiliation: Perioperative and Pain Medicine Unit, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria 3010, Australia
Issue Date: 1-Sep-2013
Publication information: Anesthesiology; 119(3): 569-75
Abstract: In an incidental finding, during a study of plasma chemistry after crystalloid infusion, participants reported subjective cognitive changes, particularly slower thinking, after saline but not Hartmann's (Ringer's lactate) solution. The authors tested the hypothesis that saline infusion would produce greater adverse cognitive changes than Plasmalyte infusion.The authors conducted a randomized, cross-over, multiple blinded study of healthy adult volunteers. On separate days, participants received 30 ml/kg over 1 h of either 0.9% saline or Plasmalyte with the order randomly allocated. Plasma chemistry was tested on venous samples. As part of a battery of cognitive tests our primary endpoint was the reaction time index after infusion.The authors studied 25 participants. Plasma chloride was greater after saline than after Plasmalyte: mean difference 5.4 mM (95% CI, 4.1-6.6 mM; P < 0.001). Saline was also associated with greater metabolic acidosis: base-excess 2.5 mM more negative (95% CI, 1.9-3.0 mM more negative; P < 0.001). There was no evidence of a difference in the reaction time index between the two interventions: mean reaction time index 394 ms (SD, 72) after saline versus 385 ms (SD, 55) after Plasmalyte. Difference: saline 9 ms slower (95% CI, 30 ms slower to 12 ms faster; P = 0.39). There were minimal differences in the other cognitive and mood tests.Despite expected differences in plasma chemistry, the authors found that measures of cognition did not differ after infusions of Plasmalyte or saline.
Gov't Doc #: 23598288
DOI: 10.1097/ALN.0b013e31829416ba
Type: Journal Article
Subjects: Acidosis.chemically induced
Cognition.drug effects
Cross-Over Studies
Gluconates.adverse effects
Magnesium Chloride.adverse effects
Middle Aged
Potassium Chloride.adverse effects
Reaction Time.drug effects
Sodium Acetate.adverse effects
Sodium Chloride.adverse effects
Appears in Collections:Journal articles

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