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Title: Head-to-head comparison of 11C-PiB and 18F-AZD4694 (NAV4694) for β-amyloid imaging in aging and dementia.
Austin Authors: Rowe, Christopher C ;Pejoska, Svetlana;Mulligan, Rachel S ;Jones, Gareth;Chan, J Gordon ;Svensson, Samuel;Cselényi, Zsolt;Masters, Colin L ;Villemagne, Victor L 
Affiliation: Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 10-Apr-2013
Publication information: Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 2013; 54(6): 880-6
Abstract: (11)C-Pittsburgh compound-B ((11)C-PiB) is the benchmark radiotracer for imaging of β-amyloid (Aβ) plaque in Alzheimer disease (AD). (18)F-labeled Aβ tracers subsequently developed for clinical use show higher nonspecific white matter binding and, in some cases, lower cortical binding in AD that could lead to less accurate interpretation of scans. We compared the cortical and white matter binding of a new (18)F-labeled Aβ tracer, (18)F-AZD4694 (recently renamed NAV4694), with (11)C-PiB in the same subjects.Forty-five participants underwent PET imaging with (11)C-PiB and (18)F-AZD4694 (25 healthy elderly controls [HCs], 10 subjects with mild cognitive impairment, 7 subjects with probable AD, and 3 subjects with probable frontotemporal dementia). Images were coregistered so that region-of-interest placement was identical on both scans, and standardized uptake value ratios (SUVRs) using the cerebellar cortex as a reference region were calculated between 40 and 70 min after injection for both tracers.(18)F-AZD4694 showed reversible binding kinetics similar to (11)C-PiB, reaching an apparent steady state at 50 min after injection. Both radiotracers showed a similar dynamic range of neocortical SUVR (1.1-3.3 and 1.0-3.2 SUVR for (11)C-PiB and (18)F-AZD4694, respectively) and identical low nonspecific white matter binding, with frontal cortex-to-white matter ratios of 0.7 ± 0.2 and 1.3 ± 0.2 for both radiotracers in HCs and AD subjects, respectively. There was an excellent linear correlation between (11)C-PiB and (18)F-AZD4694 neocortical SUVR (slope of 0.95, r = 0.99, P < 0.0001).(18)F-AZD4694 displays imaging characteristics nearly identical to those of (11)C-PiB. The low white matter and high cortical binding in AD indicate that this tracer is well suited to both clinical and research use.
DOI: 10.2967/jnumed.112.114785
Journal: Journal of Nuclear Medicine
Type: Journal Article
Subjects: Alzheimer’s disease

amyloid imaging
positron emission tomography
Amyloid beta-Peptides.metabolism
Benzofurans.diagnostic use.metabolism
Benzothiazoles.diagnostic use.metabolism
Brain.metabolism.radionuclide imaging
Dementia.metabolism.radionuclide imaging
Hydrocarbons, Fluorinated.diagnostic use.metabolism
Molecular Imaging.methods
Positron-Emission Tomography
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