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Title: Vancomycin minimum inhibitory concentration, host comorbidities and mortality in Staphylococcus aureus bacteraemia.
Austin Authors: Holmes, Natasha E ;Turnidge, J D;Munckhof, Wendy J;Robinson, J O;Korman, Tony M;O'Sullivan, Matthew V N;Anderson, Tara L;Roberts, S A;Warren, S J C;Gao, W;Johnson, Paul D R ;Howden, Benjamin P 
Affiliation: Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
Austin Centre for Infection Research, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 26-Feb-2013
Publication information: Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2013; 19(12): 1163-8
Abstract: We reported an association between elevated vancomycin MIC and 30-day mortality in patients with Staphylococcus aureus bacteraemia (SAB), including patients with methicillin-susceptible S. aureus (MSSA) treated with flucloxacillin. A detailed analysis of comorbidities and disease severity scores in the same cohort of patients was performed to ascertain if unknown clinical parameters may have influenced these results. The association between elevated vancomycin MIC and 30-day mortality in SAB remained significant (p 0.001) on multivariable logistic regression analysis even when accounting for clinical factors. In addition, the association persisted when restricting analysis to patients with MSSA bacteraemia treated with flucloxacillin. This suggests that elevated vancomycin MIC is associated with but not causally linked to an organism factor that is responsible for increased mortality.
Gov't Doc #: 23441652
DOI: 10.1111/1469-0691.12168
Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Type: Journal Article
Subjects: Bacteraemia
Staphylococcus aureus
vancomycin minimum inhibitory concentration
Anti-Bacterial Agents.pharmacology.therapeutic use
Bacteremia.drug therapy.microbiology.mortality
Child, Preschool
Infant, Newborn
Logistic Models
Methicillin-Resistant Staphylococcus aureus.drug effects
Microbial Sensitivity Tests
Middle Aged
Retrospective Studies
Staphylococcal Infections.drug therapy.microbiology.mortality
Staphylococcus aureus.drug effects
Treatment Outcome
Vancomycin.pharmacology.therapeutic use
Young Adult
Appears in Collections:Journal articles

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