(18)F-florbetaben Aβ imaging in mild cognitive impairment.

2013-01-16

Ong, Kevin

Villemagne, Victor L

Bahar-Fuchs, Alex

Lamb, Fiona

Chételat, Gaël

Raniga, Parnesh

Mulligan, Rachel S

Salvado, Olivier

Putz, Barbara

Roth, Katrin

Masters, Colin L

Reininger, Cornelia B

Rowe, Christopher C

Journal Article

10.1186/alzrt158

(18)F-florbetaben and positron emission tomography were used to examine the relationships between β-amyloid (Aβ) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impairment (MCI).Forty-five MCI participants were evaluated. A neocortical standardized uptake value ratio threshold ≥ 1.45 was used to discriminate high from low Aβ burden. Correlations were adjusted for age, gender and years of education.High Aβ burden was found in 53% of MCI. Regression analyses showed standardized uptake value ratio (r = -0.51, P = 0.0015) and hippocampal volume (r = 0.60, P = 0.024) both contributing to episodic memory impairment in independent fashion. White matter hyperintensities correlated with nonmemory cognition, and this correlation was particularly associated with Aβ burden.Higher Aβ deposition in MCI is associated with more severe memory impairment and is contributing to early amnestic symptoms independent of hippocampal atrophy.

link

Alzheimer's Research & Therapy 2013; 5(1): 4

Alzheimer's research & therapy