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Title: Cortical excitability and refractory epilepsy: a three-year longitudinal transcranial magnetic stimulation study.
Austin Authors: Badawy, Radwa A B;Jackson, Graeme D ;Berkovic, Samuel F ;Macdonell, Richard A L 
Affiliation: Department of Neurology, Austin Health, Heidelberg, Epilepsy Research Centre, Australia
Issue Date: 3-Dec-2012
Publication information: International Journal of Neural Systems 2012; 23(1): 1250030
Abstract: Transcranial magnetic stimulation was used to study the effect of recurrent seizures on cortical excitability over time in epilepsy. 77 patients with firm diagnoses of idiopathic generalized epilepsy (IGE) or focal epilepsy were repeatedly evaluated over three years. At onset, all groups had increased cortical excitability. At the end of follow-up the refractory group was associated with a broad increase in cortical excitability. Conversely, cortical excitability decreased in all seizure free groups after introduction of an effective medication.
Gov't Doc #: 23273126
DOI: 10.1142/S012906571250030X
Journal: International journal of neural systems
Type: Journal Article
Subjects: Adult
Anticonvulsants.therapeutic use
Cerebral Cortex.drug effects.physiopathology
Epilepsies, Partial.drug therapy.physiopathology.therapy
Epilepsy.drug therapy.physiopathology.therapy
Evoked Potentials, Motor.physiology
Middle Aged
Transcranial Magnetic Stimulation.instrumentation.methods
Young Adult
Appears in Collections:Journal articles

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