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Title: Bone mineralization: from tissue to crystal in normal and pathological contexts.
Austin Authors: Bala, Yohann;Farlay, D;Boivin, G
Affiliation: Endocrine Center, Austin Health, University of Melbourne, Melbourne, Australia
Issue Date: 11-Dec-2012
Publication information: Osteoporosis International : A Journal Established As Result of Cooperation Between the European Foundation For Osteoporosis and the National Osteoporosis Foundation of The Usa 2012; 24(8): 2153-66
Abstract: Bone is a complex and structured material; its mechanical behavior results from an interaction between the properties of each level of its structural hierarchy. The degree of mineralization of bone (bone density measured at tissue level) and the characteristics of the mineral deposited (apatite crystals) are major determinants of bone strength. Bone remodeling activity acts as a regulator of the degree of mineralization and of the distribution of mineral at the tissue level, directly impacting bone mechanical properties. Recent findings have highlighted the need to understand the underlying process occurring at the nanostructure level that may be independent of bone remodeling itself. A more global comprehension of bone qualities will need further works designed to characterize what are the consequences on whole bone strength of changes at nano- or microstructure levels relative to each other.
Gov't Doc #: 23229470
DOI: 10.1007/s00198-012-2228-y
Journal: Osteoporosis International
Type: Journal Article
Subjects: Aging.physiology
Bone Density.physiology
Bone Diseases.pathology.physiopathology
Bone Remodeling.physiology
Bone and Bones.chemistry.ultrastructure
Osteoporosis, Postmenopausal.pathology.physiopathology
Appears in Collections:Journal articles

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