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Title: Plasma concentrations of melatonin in panic disorder.
Austin Authors: McIntyre, I M;Judd, F K;Burrows, Graham D;Armstrong, S M;Norman, Trevor R 
Affiliation: Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Apr-1990
Publication information: The American Journal of Psychiatry; 147(4): 462-4
Abstract: Nocturnal plasma melatonin concentrations were measured in seven patients with panic disorder and eight healthy control subjects. The five patients who had never received psychotropic medication had significantly greater melatonin concentrations from 4:00 a.m. to 7:00 a.m. than the control subjects. In addition it is possible that a phase delay occurred in these unmedicated patients. The findings are discussed in terms of previous studies showing increased melatonin in manic patients and the effect of intense stress on melatonin synthesis. The two patients who had been medication free for only 1 week showed a decreased melatonin rhythm, which is consistent with previous findings in medicated patients.
Gov't Doc #: 2316732
Type: Journal Article
Subjects: Adult
Alprazolam.therapeutic use
Anxiety Disorders.blood.drug therapy.psychology
Circadian Rhythm
Psychotropic Drugs.therapeutic use
Appears in Collections:Journal articles

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