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Title: Androgens, diabetes and prostate cancer.
Austin Authors: Grossmann, Mathis ;Wittert, Gary
Affiliation: Department of Medicine Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 5-Sep-2012
Publication information: Endocrine-related Cancer 2012; 19(5): F47-62
Abstract: Metabolic disorders such as diabetes, obesity and the metabolic syndrome have been shown to modulate prostate cancer (PCa) risk and aggressiveness in population-based and experimental studies. While associations between these conditions are modest and complex, two consistent findings have emerged. First, there is observational evidence that obesity and associated insulin excess are linked to increased PCa aggressiveness and worse outcomes. Secondly and somewhat paradoxically, long-standing diabetes may be protective against PCa development. This apparent paradox may be due to the fact that long-standing diabetes is associated with insulin depletion and decreased IGF1 signalling. Men with obesity or diabetes have moderate reductions in their androgen levels. The interconnectedness of metabolic and androgen status complicates the dissection of the individual roles of these factors in PCa development and progression. Metabolic factors and androgens may promote prostate carcinogenesis via multiple mechanisms including inflammation, adipokine action, fatty acid metabolism and IGF signalling. Moreover, androgen deprivation, given to men with PCa, has adverse metabolic consequences that need to be taken into account when estimating the risk benefit ratio of this therapy. In this review, we will discuss the current epidemiological and mechanistic evidence regarding the interactions between metabolic conditions, sex steroids and PCa risk and management.
Gov't Doc #: 22514110
DOI: 10.1530/ERC-12-0067
Type: Journal Article
Subjects: Androgens.metabolism
Diabetes Mellitus.epidemiology.metabolism
Prostatic Neoplasms.epidemiology.metabolism
Appears in Collections:Journal articles

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