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Title: Accelerated cortical atrophy in cognitively normal elderly with high β-amyloid deposition.
Austin Authors: Chételat, G;Villemagne, Victor L ;Villain, N;Jones, G;Ellis, Kathryn A;Ames, David;Martins, Ralph N;Masters, Colin L ;Rowe, Christopher C 
Institutional Author: AIBL Research Group
Department of Nuclear Medicine, Austin Health, Melbourne, Australia
Issue Date: 1-Feb-2012
Publication information: Neurology 2012; 78(7): 477-84
Abstract: Given the recent and growing interest in the concepts of prodromal and presymptomatic Alzheimer disease, it is crucial to determine whether the presence of β-amyloid (Aβ) in the brain of asymptomatic elderly individuals is a pathologic condition associated with accelerated neuronal and synaptic loss. The aim of the present study was to assess whether Aβ influences the rate of atrophy in cognitively normal elderly individuals.Seventy-four healthy elderly individuals underwent an MRI scan and a 11C-Pittsburgh compound B (PiB) PET scan at baseline and a second MRI scan 18 months later. Voxel-wise analyses were performed using maps of annual rate of atrophy generated from the serial MRI scans, including comparison between individuals with high vs low neocortical PiB and correlation with baseline neocortical PiB.The rate of atrophy was significantly higher in the normal elderly individuals with high PiB compared with those with low PiB and was significantly correlated with baseline neocortical PiB, with the highest significance in the temporal neocortex and the posterior cingulate cortex.Our findings show that the presence of Aβ in the brain, known to occur in about one-third of asymptomatic elderly individuals, is actually a pathologic state associated with accelerated atrophy. They also suggest that therapy aimed to reduce the neurodegenerative process should be commenced in presymptomatic individuals with high PiB.
DOI: 10.1212/WNL.0b013e318246d67a
Type: Journal Article
Subjects: Aged
Aged, 80 and over
Amyloid beta-Peptides.metabolism
Aniline Compounds.diagnostic use
Brain Mapping
Cerebral Cortex.pathology.radionuclide imaging
Disease Progression
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Mild Cognitive Impairment.pathology.psychology
Positron-Emission Tomography
Radiopharmaceuticals.diagnostic use
Thiazoles.diagnostic use
Appears in Collections:Journal articles

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