Austin Health

Title
Comparison of immunoglobulin G subclass concentrations in severe community-acquired pneumonia and severe pandemic 2009 influenza A (H1N1) infection.
Publication Date
2012-01-11
Author(s)
Gordon, Claire L
Holmes, Natasha E
Grayson, M Lindsay
Torresi, Joseph
Johnson, Paul D R
Cheng, Allen C
Charles, Patrick G P
Type of document
Journal Article
OrcId
#PLACEHOLDER_PARENT_METADATA_VALUE#
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#PLACEHOLDER_PARENT_METADATA_VALUE#
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DOI
10.1128/CVI.05518-11
Abstract
We compared immunoglobulin G (IgG) subclasses in patients with severe noninfluenza community-acquired pneumonia (CAP) to those in patients with severe pandemic 2009 influenza (H1N1) virus infection. Low IgG1 and IgG2 levels occurred often in the CAP group; however, H1N1 patients had lower IgG1 and IgG2 levels (5.4 versus 3.3 g/liter [P = 0.008] and 2.5 versus 1.2 g/liter [P < 0.001], respectively). Low IgG2 levels may be specifically linked to severe H1N1; however, it is not clear whether this association is related to H1N1 or to other features of severity.
Link
Citation
Clinical and Vaccine Immunology : Cvi 2012; 19(3): 446-8
Jornal Title
Clinical and Vaccine Immunology : CVI

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