Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11372
Title: P-21 activated kinase 1 knockdown inhibits β-catenin signalling and blocks colorectal cancer growth.
Austin Authors: He, Hong ;Huynh, Nhi;Liu, Kevin H;Malcontenti-Wilson, Caterina;Zhu, Jin;Christophi, Christopher ;Shulkes, Arthur;Baldwin, Graham S
Affiliation: Department of Surgery, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia 3084, Australia
Issue Date: 15-Nov-2011
Publication information: Cancer Letters 2011; 317(1): 65-71
Abstract: The p21-activated kinase 1 (PAK1) plays important roles in cell growth, motility, and transformation. The aims of this study were to delineate the signalling mechanisms downstream of PAK1, and to investigate the importance of PAK1 for colorectal cancer (CRC) growth and metastasis in vivo. PAK1 knockdown in human CRC cell lines inhibited β-catenin expression, β-catenin/TCF4 transcriptional activity, and the expression of c-Myc. In mouse models PAK1 knockdown suppressed the growth and metastasis of human CRC cells by decreasing proliferation and increasing apoptosis. Our findings demonstrate for the first time the crucial role of PAK1 in CRC progression in vivo.
Gov't Doc #: 22100495
URI: http://ahro.austin.org.au/austinjspui/handle/1/11372
DOI: 10.1016/j.canlet.2011.11.014
URL: https://pubmed.ncbi.nlm.nih.gov/22100495
Type: Journal Article
Subjects: Animals
Apoptosis
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors.metabolism
Cell Proliferation
Colorectal Neoplasms.enzymology.genetics.pathology
Gene Knockdown Techniques
HCT116 Cells
HT29 Cells
Humans
Liver Neoplasms.enzymology.genetics.secondary
Mice
Mice, SCID
Neoplasm Invasiveness
Proto-Oncogene Proteins c-myc.metabolism
RNA Interference
Signal Transduction
Time Factors
Transcription Factors.metabolism
Transfection
Tumor Burden
Xenograft Model Antitumor Assays
beta Catenin.genetics.metabolism
p21-Activated Kinases.deficiency.genetics
Appears in Collections:Journal articles

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