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https://ahro.austin.org.au/austinjspui/handle/1/11372| Title: | P-21 activated kinase 1 knockdown inhibits β-catenin signalling and blocks colorectal cancer growth. | Austin Authors: | He, Hong ;Huynh, Nhi;Liu, Kevin H;Malcontenti-Wilson, Caterina;Zhu, Jin;Christophi, Christopher ;Shulkes, Arthur;Baldwin, Graham S | Affiliation: | Department of Surgery, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia 3084, Australia | Issue Date: | 15-Nov-2011 | Publication information: | Cancer Letters 2011; 317(1): 65-71 | Abstract: | The p21-activated kinase 1 (PAK1) plays important roles in cell growth, motility, and transformation. The aims of this study were to delineate the signalling mechanisms downstream of PAK1, and to investigate the importance of PAK1 for colorectal cancer (CRC) growth and metastasis in vivo. PAK1 knockdown in human CRC cell lines inhibited β-catenin expression, β-catenin/TCF4 transcriptional activity, and the expression of c-Myc. In mouse models PAK1 knockdown suppressed the growth and metastasis of human CRC cells by decreasing proliferation and increasing apoptosis. Our findings demonstrate for the first time the crucial role of PAK1 in CRC progression in vivo. | Gov't Doc #: | 22100495 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/11372 | DOI: | 10.1016/j.canlet.2011.11.014 | Journal: | Cancer letters | URL: | https://pubmed.ncbi.nlm.nih.gov/22100495 | Type: | Journal Article | Subjects: | Animals Apoptosis Basic Helix-Loop-Helix Leucine Zipper Transcription Factors.metabolism Cell Proliferation Colorectal Neoplasms.enzymology.genetics.pathology Gene Knockdown Techniques HCT116 Cells HT29 Cells Humans Liver Neoplasms.enzymology.genetics.secondary Mice Mice, SCID Neoplasm Invasiveness Proto-Oncogene Proteins c-myc.metabolism RNA Interference Signal Transduction Time Factors Transcription Factors.metabolism Transfection Tumor Burden Xenograft Model Antitumor Assays beta Catenin.genetics.metabolism p21-Activated Kinases.deficiency.genetics |
| Appears in Collections: | Journal articles |
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