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Title: Duloxetine in the acute and continuation treatment of major depressive disorder.
Austin Authors: Bochsler, Lanny;Olver, James S ;Norman, Trevor R 
Affiliation: Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria 3084, Australia
Issue Date: 1-Nov-2011
Publication information: Expert Review of Neurotherapeutics; 11(11): 1525-39
Abstract: Duloxetine is a serotonin-noradrenaline reuptake inhibitor with indications for use in the short term, continuation and maintenance treatment of major depression. Although clinicians currently have access to a range of medications for the treatment of depression, a significant number of patients fail to respond or remit from their illness despite adequate trials of treatment with multiple agents. A developing concept is that antidepressant strategies that combine multiple mechanisms of action may have advantages over agents with single mechanisms (i.e., selective serotonin reuptake inhibitors). As a dual-acting agent, duloxetine offers the promise of advantages in terms of efficacy over selective serotonin reuptake inhibitors while retaining a favorable safety and tolerability profile in comparison to older agents. Likewise, duloxetine is of interest in the treatment of certain conditions commonly seen in conjunction with major depression, particularly anxiety and pain, both of which may respond more favorably to agents that act on both serotonin and noradrenaline neurotransmitter systems.
Gov't Doc #: 22014130
DOI: 10.1586/ern.11.133
Type: Journal Article
Subjects: Antidepressive Agents.pharmacology.therapeutic use
Clinical Trials as Topic
Depressive Disorder, Major.drug therapy
Thiophenes.pharmacology.therapeutic use
Appears in Collections:Journal articles

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