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Title: Comparison of simvastatin and cholestyramine in the treatment of primary hypercholesterolaemia.
Austin Authors: O'Brien, R C;Simons, L A;Clifton, P;Cooper, Mark E;Jennings, G L;Jerums, George ;Nestel, P J;Sullivan, D
Affiliation: Department of Medicine, Austin Hospital, Heidelberg, VIC.
Issue Date: 7-May-1990
Publication information: Medical Journal of Australia; 152(9): 480-3
Abstract: The effects of simvastatin, a competitive inhibitor of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase, on plasma lipid levels were compared with those of the bile acid sequestrant cholestyramine in a randomized parallel study of 60 subjects with primary hypercholesterolaemia. After a 12-week direct comparison period 37 subjects with inadequate cholesterol reduction received a combination of both drugs and all subjects were followed for a further 40 weeks. Simvastatin was more effective than cholestyramine in lowering total and LDL cholesterol levels and the LDL/HDL ratio (-31.7% v. -19.7% [P less than 0.01], -41.0% v. -31.8% [P less than 0.05] and -46.7% v. -33.6% [P less than 0.01], respectively at Week 12). Only simvastatin significantly increased the HDL cholesterol concentration (+13.3% [P less than 0.01] v. +6.4%). Cholestyramine increased plasma triglyceride levels by 37.5% (P less than 0.01) whereas simvastatin caused a slight non-significant reduction. Combined therapy produced a further decrease in total and LDL cholesterol levels, and in the LDL/HDL ratio, which was sustained for the duration of the study. Simvastatin was better tolerated than cholestyramine (P less than 0.01), and combining the two drugs enhanced efficacy without increasing the frequency of side effects.
Gov't Doc #: 2199801
Type: Journal Article
Subjects: Adult
Analysis of Variance
Anticholesteremic Agents.administration & dosage.therapeutic use
Cholestyramine Resin.administration & dosage.therapeutic use
Drug Therapy, Combination
Follow-Up Studies
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypercholesterolemia.blood.drug therapy.enzymology
Lovastatin.administration & dosage.analogs & derivatives.therapeutic use
Middle Aged
Multicenter Studies as Topic
Randomized Controlled Trials as Topic
Appears in Collections:Journal articles

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