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Title: | Comparison of simvastatin and cholestyramine in the treatment of primary hypercholesterolaemia. | Austin Authors: | O'Brien, R C;Simons, L A;Clifton, P;Cooper, Mark E;Jennings, G L;Jerums, George ;Nestel, P J;Sullivan, D | Affiliation: | Department of Medicine, Austin Hospital, Heidelberg, VIC. | Issue Date: | 7-May-1990 | Publication information: | Medical Journal of Australia; 152(9): 480-3 | Abstract: | The effects of simvastatin, a competitive inhibitor of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase, on plasma lipid levels were compared with those of the bile acid sequestrant cholestyramine in a randomized parallel study of 60 subjects with primary hypercholesterolaemia. After a 12-week direct comparison period 37 subjects with inadequate cholesterol reduction received a combination of both drugs and all subjects were followed for a further 40 weeks. Simvastatin was more effective than cholestyramine in lowering total and LDL cholesterol levels and the LDL/HDL ratio (-31.7% v. -19.7% [P less than 0.01], -41.0% v. -31.8% [P less than 0.05] and -46.7% v. -33.6% [P less than 0.01], respectively at Week 12). Only simvastatin significantly increased the HDL cholesterol concentration (+13.3% [P less than 0.01] v. +6.4%). Cholestyramine increased plasma triglyceride levels by 37.5% (P less than 0.01) whereas simvastatin caused a slight non-significant reduction. Combined therapy produced a further decrease in total and LDL cholesterol levels, and in the LDL/HDL ratio, which was sustained for the duration of the study. Simvastatin was better tolerated than cholestyramine (P less than 0.01), and combining the two drugs enhanced efficacy without increasing the frequency of side effects. | Gov't Doc #: | 2199801 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/11354 | Journal: | Medical Journal of Australia | URL: | https://pubmed.ncbi.nlm.nih.gov/2199801 | Type: | Journal Article | Subjects: | Adult Aged Analysis of Variance Anticholesteremic Agents.administration & dosage.therapeutic use Australia Cholesterol.blood Cholestyramine Resin.administration & dosage.therapeutic use Drug Therapy, Combination Female Follow-Up Studies Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Hypercholesterolemia.blood.drug therapy.enzymology Lovastatin.administration & dosage.analogs & derivatives.therapeutic use Male Middle Aged Multicenter Studies as Topic Randomized Controlled Trials as Topic Simvastatin Triglycerides.blood |
Appears in Collections: | Journal articles |
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