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Title: Selecting appropriate voxel-based methods for neuroimaging studies.
Austin Authors: Abbott, David F ;Pell, Gaby S;Pardoe, Heath R;Jackson, Graeme D 
Affiliation: Florey Neuroscience Institutes, Melbourne Brain Centre, Austin Hospital, Victoria, Australia
Issue Date: 6-Jul-2011
Publication information: Neuroimage 2011; 59(2): 885-6
Abstract: We highlight a fundamental difference between voxel-based methods that interrogate signal intensity directly and those that interrogate morphometric features; we discuss how signal intensity changes might erroneously affect morphometric measures, and we provide some guidance for selection of appropriate methods to address particular hyphotheses. Our discussion is motivated by a recent application of voxel-based morphometry methods to T2-weighted images (T2-Voxel Based Morphometry; T2-VBM). In this context we discuss alternative approaches including Voxel-Based T2-Relaxometry (VBR) and Voxel Based Iterative Sensitivity analysis of T2-Weighted Images (VBIS-T2).
Gov't Doc #: 21763436
DOI: 10.1016/j.neuroimage.2011.06.083
Journal: NeuroImage
Type: Journal Article
Subjects: Alzheimer Disease.pathology
Image Interpretation, Computer-Assisted.methods
Imaging, Three-Dimensional.methods
Magnetic Resonance Imaging.methods
Appears in Collections:Journal articles

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