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Title: Reduced V1 vasopressin binding in the rat nucleus solitarii after nodose ganglionectomy.
Austin Authors: Phillips, P A;Widdop, Robert E;Chai, Syn Y;Kelly, J;Mooser, V;Trinder, D;Johnston, Colin I
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Apr-1990
Publication information: Clinical and Experimental Pharmacology & Physiology; 17(4): 321-5
Abstract: 1. Anaesthetized male Sprague-Dawley rats underwent unilateral nodose ganglionectomy or sham operation. 2. One week later hindbrain V1 vasopressin binding site density was assessed by in vitro autoradiography with the selective V1 antagonist radioligand [125I] [d(CH2)5, Sar7]AVP. 3. Specific binding was observed in the nodose ganglion, nucleus tractus solitarius (NTS), area postrema, and inferior olive. Only binding in the medial subnucleus of the NTS was reduced by ipsilateral nodose ganglionectomy. 4. These findings are consistent with V1 vasopressin receptors occurring presynaptically on vagal primary viscerosensory afferent fibres. 5. Such receptors may be involved in the effect of AVP on blood pressure and/or the baroreflex.
Gov't Doc #: 2140739
Journal: Clinical and Experimental Pharmacology & Physiology
Type: Journal Article
Subjects: Animals
Medulla Oblongata.metabolism
Nodose Ganglion.physiology
Rats, Inbred Strains
Receptors, Angiotensin.metabolism
Receptors, Vasopressin
Vagus Nerve.physiology
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