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Title: Daptomycin non-susceptibility in vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous-VISA (hVISA): implications for therapy after vancomycin treatment failure.
Austin Authors: Kelley, Peter G;Gao, Wei;Ward, Peter B;Howden, Benjamin P 
Affiliation: Microbiology
Issue Date: 2-Mar-2011
Publication information: The Journal of Antimicrobial Chemotherapy 2011; 66(5): 1057-60
Abstract: The aim of this study was to establish the relationship between reduced vancomycin and daptomycin susceptibility among Australasian vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous-VISA (hVISA) isolates from patients never exposed to daptomycin.Forty-seven stored clinical isolates of hVISA/VISA collected before November 2008 from around Australia and New Zealand were selected. Daptomycin and vancomycin MIC testing was performed using broth microdilution (BMD) and Etest methods. Daptomycin population analysis was performed on a subset of isolates.The percentage of daptomycin non-susceptible isolates was 0% for vancomycin-susceptible S. aureus (VSSA) (Etest and BMD), for hVISA it was 26% by Etest and 15% by BMD, and for VISA 62% by Etest and 38% by BMD. Population analysis profile testing demonstrated daptomycin heteroresistance among the hVISA and VISA strains tested.This is the highest rate of daptomycin non-susceptibility reported among hVISA isolates to date. Clinicians should exhibit caution when using daptomycin in situations where serious hVISA or VISA infection is a possibility.
DOI: 10.1093/jac/dkr066
Journal: The Journal of Antimicrobial Chemotherapy
Type: Journal Article
Subjects: Anti-Bacterial Agents.pharmacology.therapeutic use
Daptomycin.pharmacology.therapeutic use
Drug Resistance, Bacterial
Microbial Sensitivity Tests
New Zealand
Staphylococcal Infections.drug therapy.microbiology
Staphylococcus aureus.drug effects.isolation & purification
Treatment Failure
Vancomycin.pharmacology.therapeutic use
Appears in Collections:Journal articles

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