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Title: Intracanal pressure in compressive spinal cord injury: reduction with hypothermia.
Austin Authors: Batchelor, Peter Egerton;Kerr, Nicole F;Gatt, Amy M;Cox, Susan F;Ghasem-Zadeh, Ali ;Wills, Taryn E;Sidon, Tara K;Howells, David William
Department of Medicine, National Stroke Research Institute and University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 24-Mar-2011
Publication information: Journal of Neurotrauma 2011; 28(5): 809-20
Abstract: Most cases of human spinal cord injury (SCI) are accompanied by continuing cord compression. Experimentally, compression results in rapid neurological decline over hours, suggesting a rise in intracanal pressure local to the site of injury. The aim of this study was to measure the rise in local intracanal pressure accompanying progressive canal occlusion and to determine the relationship between raised intracanal pressure and neurological outcome. We also aimed to establish whether hypothermia was able to reduce raised intracanal pressure. We demonstrate that, following SCI in F344 rats, local intracanal pressure remains near normal until canal occlusion exceeds 30% of diameter, whereupon a rapid increase in pressure occurs. Intracanal pressure appears to be an important determinant of neurological recovery, with poor long-term behavioural and histological outcomes in animals subject to 8 h of 45% canal occlusion, in which intracanal pressure is significantly elevated. In contrast, good neurological recovery occurs in animals with near normal intracanal pressure (animals undergoing 8 h of 30% canal occlusion or those undergoing immediate decompression). We further demonstrate that hypothermia is an effective therapy to control raised intracanal pressure, rapidly reducing elevated intracanal pressure accompanying critical (45%) canal occlusion to near normal. Overall these data indicate that following SCI only limited canal narrowing is tolerated before local intracanal pressure rapidly rises, inducing a sharp decline in neurological outcome. Raised intracanal pressure can be controlled with hypothermia, which may be a useful therapy to emergently decompress the spinal cord prior to surgical decompression.
Gov't Doc #: 21250916
DOI: 10.1089/neu.2010.1622
Type: Journal Article
Subjects: Animals
Disease Models, Animal
Hypothermia, Induced
Rats, Inbred F344
Spinal Canal.pathology.physiopathology
Spinal Cord Compression.etiology.physiopathology.therapy
Spinal Cord Injuries.complications.physiopathology.therapy
Spinal Stenosis.etiology.physiopathology.therapy
Appears in Collections:Journal articles

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