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Title: Urinary hepcidin: an inverse biomarker of acute kidney injury after cardiopulmonary bypass?
Austin Authors: Prowle, John R;Westerman, Mark;Bellomo, Rinaldo 
Affiliation: Department of Intensive Care Medicine, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 1-Dec-2010
Publication information: Current Opinion in Critical Care; 16(6): 540-4
Abstract: In this review, we discuss the potential role of urinary hepcidin, a 2.8-kDa hormonal regulator of iron metabolism, as a biomarker of acute kidney injury (AKI) after cardiopulmonary bypass.Hepcidin is one of the novel biomarkers of AKI that have been identified using hypothesis-free, proteomic analysis of urine or plasma in patients who develop AKI. Collectively, these markers promise a new era for the early diagnosis and treatment of AKI in the ICU and an understanding of their biological role may also provide mechanistic insights into the pathogenesis of AKI. Although data confirming the association between urinary hepcidin and AKI are as yet limited, we believe hepcidin is of particular interest because hepcidin may be a biomarker specific to cardiopulmonary bypass-associated AKI; as a central regulator of iron metabolism, hepcidin could play a biological role in the pathogenesis of AKI after cardiopulmonary bypass; and hepcidin displays an intriguing negative association with AKI, in that a smaller increase in hepcidin from baseline after cardiopulmonary bypass appears to predict greater chance of developing AKI.Smaller increases in urinary hepcidin, a central regulator of iron metabolism, may be associated with greater risk of AKI after cardiopulmonary bypass. Further research is required to establish the significance and nature of this association.
Gov't Doc #: 20736824
DOI: 10.1097/MCC.0b013e32833ecdcc
Journal: Current opinion in critical care
Type: Journal Article
Subjects: Acute Kidney Injury.diagnosis.etiology.urine
Acute-Phase Proteins.metabolism
Antimicrobial Cationic Peptides.metabolism.urine
Biological Markers
Cardiopulmonary Bypass.adverse effects
Critical Illness
Postoperative Complications.diagnosis
Proto-Oncogene Proteins.metabolism
Sensitivity and Specificity
Appears in Collections:Journal articles

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