Austin Health

Title
Carbimazole-induced agranulocytosis: does antineutrophil cytoplasmic antibody have a role?
Publication Date
2010-04-01
Author(s)
Yip, G
Ekinci, Elif I
Lee, S T
Jerums, George
Grossmann, Mathis
Type of document
Journal Article
DOI
10.1111/j.1445-5994.2009.02143.x
Abstract
Carbimazole is a drug that is widely used for hyperthyroid disorders, such as Graves' disease. Agranulocytosis is a rare idiosyncratic adverse reaction to the drug which is potentially fatal. This report describes a patient with a history of successfully treated pyoderma gangrenosum, who developed agranulocytosis 3 weeks after commencement of carbimazole for Graves' disease. It may give credence to the theory that implicates antineutrophil cytoplasmic antibodies in the pathogenesis of agranulocytosis induced by antithyroid drugs.
Link
Citation
Internal Medicine Journal; 40(4): 300-3
Jornal Title
Internal Medicine Journal

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