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Title: Oral bioavailability of omeprazole before and after chronic therapy in patients with duodenal ulcer.
Austin Authors: Ching, M S;Mihaly, G W;Angus, Peter W ;Morgan, Denis J;Devenish-Meares, S;Yeomans, Neville D ;Smallwood, R A
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Australia
Issue Date: 1-Feb-1991
Publication information: British Journal of Clinical Pharmacology; 31(2): 166-70
Abstract: 1. This study investigated the mechanism of the increase in oral bioavailability of omeprazole during repeated oral dosing. Eight patients with duodenal ulcer received an i.v. dose of omeprazole before and after a 4-week course of oral omeprazole, 20 mg daily, given as enteric-coated granules. 2. AUCoral and oral bioavailability (F) increased during omeprazole treatment by 50% (P less than 0.01) and 35% (P less than 0.05), respectively. 3. There was no change in the systemic clearance of omeprazole after i.v. dosage following the course of treatment. 4. We conclude that the increased omeprazole AUC observed on repeated administration of enteric-coated granules is due to increased systemic availability rather than decreased systemic elimination. The increased availability appears to be due to increased gastrointestinal absorption rather than decreased first-pass hepatic extraction.
Gov't Doc #: 2049231
Type: Journal Article
Subjects: Administration, Oral
Biological Availability
Duodenal Ulcer.drug therapy
Injections, Intravenous
Middle Aged
Omeprazole.administration & dosage.pharmacokinetics.therapeutic use
Tablets, Enteric-Coated
Appears in Collections:Journal articles

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