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Title: In vivo measurement of vesicular monoamine transporter type 2 density in Parkinson disease with (18)F-AV-133.
Austin Authors: Okamura, Nobuyuki;Villemagne, Victor L ;Drago, John;Pejoska, Svetlana;Dhamija, Rajinder K;Mulligan, Rachel S ;Ellis, Julia R;Ackermann, Uwe ;O'Keefe, Graeme J;Jones, Gareth;Kung, Hank F;Pontecorvo, Michael J;Skovronsky, Daniel;Rowe, Christopher C 
Affiliation: Department of Nuclear Medicine and Centre for PET, Austin Health, Victoria, Australia
Issue Date: 15-Jan-2010
Publication information: Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 2010; 51(2): 223-8
Abstract: PET provides a noninvasive means to evaluate the functional integrity of the presynaptic monoaminergic system in the living human brain.In this study, a novel (18)F-labeled tetrabenazine derivative, (18)F-(+)fluoropropyldihydrotetrabenazine ((18)F-AV-133), was used for the noninvasive assessment of the vesicular monoamine transporters type 2 (VMAT2) in 17 Parkinson disease (PD) patients and 6 healthy controls. The binding potential (BP) of (18)F-AV-133 was calculated using Logan graphical analysis. Voxel-based and volume-of-interest-based analyses of BP images were performed to examine brain regional reductions in VMAT2 density in PD.VMAT2 BP was decreased by 81% in the posterior putamen, 70% in the anterior putamen, and 48% in the caudate nucleus of PD patients. Voxel-based analysis demonstrated VMAT2 reductions in the striatum and mid brain of PD patients. Furthermore, VMAT2 BPs in the caudate nuclei significantly correlated with the clinical severity of PD.These findings indicate that the novel (18)F-labeled ligand (18)F-AV-133 can sensitively detect monoaminergic terminal reductions in PD patients. Studies with (18)F-AV-133 may allow the presymptomatic identification of individuals with disorders characterized by degeneration of dopaminergic nigrostriatal afferents.
DOI: 10.2967/jnumed.109.070094
Journal: Journal of Nuclear Medicine
Type: Journal Article
Subjects: Aged
Brain.metabolism.radionuclide imaging
Case-Control Studies
Caudate Nucleus.metabolism.radionuclide imaging
Corpus Striatum.metabolism.radionuclide imaging
Dopamine Plasma Membrane Transport Proteins.metabolism
Fluorine Radioisotopes.diagnostic use
Middle Aged
Parkinson Disease.metabolism.physiopathology.radionuclide imaging
Positron-Emission Tomography
Putamen.metabolism.radionuclide imaging
Radiopharmaceuticals.diagnostic use
Tetrabenazine.analogs & derivatives.diagnostic use
Tissue Distribution
Vesicular Monoamine Transport Proteins.metabolism
Appears in Collections:Journal articles

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