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Title: Early sensitivity training for parents of preterm infants: impact on the developing brain.
Austin Authors: Milgrom, Jeannette ;Newnham, Carol A;Anderson, Peter J;Doyle, Lex W;Gemmill, Alan W ;Lee, Katherine J;Hunt, Rod W;Bear, Merilyn;Inder, Terrie
Affiliation: Department of Clinical & Health Psychology, Austin Health, Victoria, Australia
Issue Date: 1-Mar-2010
Publication information: Pediatric Research; 67(3): 330-5
Abstract: After birth, preterm infants face a stressful environment, which may negatively impact early brain development and subsequent neurobehavioral outcomes. This randomized controlled trial involving 45 women with infants <30-wk gestation, assessed the effectiveness of training parents in reducing stressful experiences. Intervention consisted of 10 sessions in the Neonatal Intensive Care Unit (NICU). Postintervention, at term-equivalent (40-wk postmenstrual age), magnetic resonance imaging (MRI) was performed to evaluate brain structure and development. Quantitative volumetric techniques were used to estimate overall and regional brain volumes for different tissue types including CSF, CGM, DNGM, UWM, and MWM. DTI was used to evaluate the integrity and maturation of white matter by ADC and FA. Maturation and connectivity of white matter, characterized by diffusion MR measures of ADC and FA, were significantly enhanced in the intervention group, who displayed greater restriction in ADC and increase in FA. There were no significant effects on either brain volumes or on short-term medical outcomes. Thus, sensitivity training for parents in the NICU is associated with improved cerebral white matter micro-structural development in preterm infants.
Gov't Doc #: 19952869
DOI: 10.1203/PDR.0b013e3181cb8e2f
ORCID: 0000-0002-4082-4595
Type: Journal Article
Subjects: Adaptation, Psychological
Brain.growth & development.pathology.physiopathology
Diffusion Magnetic Resonance Imaging
Gestational Age
Infant Behavior
Infant, Newborn
Infant, Premature
Intensive Care Units, Neonatal
Intensive Care, Neonatal.methods
Maternal Behavior
Mother-Child Relations
Psychology, Child
Stress, Psychological.etiology.pathology.physiopathology.prevention & control
Time Factors
Treatment Outcome
Appears in Collections:Journal articles

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