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Title: Angiotensin II in experimental hyperdynamic sepsis.
Austin Authors: Wan, Li;Langenberg, Christoph;Bellomo, Rinaldo ;May, Clive N
Affiliation: Howard Florey Institute, University of Melbourne, Parkville, Melbourne, Victoria 3052, Australia
Issue Date: 30-Nov-2009
Publication information: Critical Care 2009; 13(6): R190
Abstract: Angiotensin II (Ang II) is a potential vasopressor treatment for hypotensive hyperdynamic sepsis. However, unlike other vasopressors, its systemic, regional blood flow and renal functional effects in hypotensive hyperdynamic sepsis have not been investigated.We performed an experimental randomised placebo-controlled animal study. We induced hyperdynamic sepsis by the intravenous administration of live E. coli in conscious ewes after chronic instrumentation with flow probes around the aorta and the renal, mesenteric, coronary and iliac arteries. We allocated animals to either placebo or angiotensin II infusion titrated to maintain baseline blood pressure.Hyperdynamic sepsis was associated with increased renal blood flow (from 292 +/- 61 to 397 +/- 74 ml/min), oliguria and a decrease in creatinine clearance (from 88.7 +/- 19.6 to 47.7 +/- 21.0 ml/min, P < 0.0001). Compared to placebo, Ang II infusion restored arterial pressure but reduced renal blood flow (from 359 +/- 81 ml/min to 279 +/- 86 ml/min; P < 0.0001). However, despite the reduction in renal blood flow, Ang II increased urine output approximately 7-fold (364 +/- 272 ml/h vs. 48 +/- 18 ml/h; P < 0.0001), and creatinine clearance by 70% (to 80.6 +/- 20.7 ml/min vs.46.0 +/- 26 ml/min; P < 0.0001). There were no major effects of Ang II on other regional blood flows.In early experimental hypotensive hyperdynamic sepsis, intravenous angiotensin II infusion decreased renal blood while inducing a marked increase in urine output and normalizing creatinine clearance.
Gov't Doc #: 19948019
DOI: 10.1186/cc8185
Type: Journal Article
Subjects: Angiotensin II.blood.pharmacology
Diuresis.drug effects
Escherichia coli Infections.blood
Hemodynamics.drug effects
Renal Circulation.drug effects
Shock, Septic.blood
Appears in Collections:Journal articles

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