Please use this identifier to cite or link to this item:
Title: Cancer stem cells in urologic cancers.
Austin Authors: Gedye, Craig;Davidson, Adee-Jonathan;Elmes, Martin R;Cebon, Jonathan S ;Bolton, Damien M ;Davis, Ian D
Affiliation: Department of Medicine, Melbourne University, Austin Health, Studley Road, Heidelberg, Australia
Issue Date: 7-Nov-2009
Publication information: Urologic Oncology 2009; 28(6): 585-90
Abstract: There is evolving evidence for the so-called cancer stem cell (CSC) hypothesis, which holds that intra-tumoral heterogeneity in urologic malignancies is hierarchical and that not all cells have the ability to proliferate indefinitely and to generate metastases. This has far-reaching implications for research and the clinical management of urologic malignancies. In this review, we outline the tenets and implications of the CSC hypothesis, summarize existing evidence for CSCs in urologic malignancies, suggest research directions that may better dissect intra-tumoral heterogeneity in urologic cancers, and outline novel therapeutic modalities implied by the CSC hypothesis.
Gov't Doc #: 19897386
DOI: 10.1016/j.urolonc.2009.06.010
Type: Journal Article
Subjects: Animals
Cell Transformation, Neoplastic.pathology
Neoplastic Stem Cells.pathology
Urologic Neoplasms.pathology
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Nov 25, 2022

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.