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|Title:||Dexamethasone-induced flares of Trichophyton rubrum masquerading as docetaxel cutaneous toxicity: a case report.||Austin Authors:||Azad, Arun A;Kaufman, Melissa;Jayarajan, Jyotsna||Affiliation:||Ludwig Institute for Cancer Research, University of Melbourne, Austin Hospital, Austin Health, 145-163 Studley Road, Heidelberg, Victoria, Australia, 3084.||Issue Date:||23-Jul-2009||Publication information:||Cases Journal 2009; 2(): 8552||Abstract:||Docetaxel chemotherapy is increasingly used in the treatment of castration-resistant prostate cancer. Cutaneous toxicity is common with docetaxel, occurring in up to 75% of cases. We present an unusual case of castration-resistant prostate cancer in which our patient developed recurrent but transient episodes of skin rash following each cycle of docetaxel. Initially, the rash was attributed to docetaxel cutaneous toxicity however a microbiological diagnosis of Trichophyton rubrum was subsequently made. We postulated that dexamethasone pre-medication transiently suppressed anti-fungal immunity, and indeed further flares were prevented by significantly reducing the dose of dexamethasone while continuing treatment with docetaxel.||Gov't Doc #:||19830081||URI:||http://ahro.austin.org.au/austinjspui/handle/1/10905||DOI:||10.4076/1757-1626-2-8552||URL:||https://pubmed.ncbi.nlm.nih.gov/19830081||Type:||Journal Article|
|Appears in Collections:||Journal articles|
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