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Title: Differences in macro- and microarchitecture of the appendicular skeleton in young Chinese and white women.
Austin Authors: Wang, Xiao-Fang ;Wang, Qingju;Ghasem-Zadeh, Ali ;Evans, Alison;McLeod, Catherine;Iuliano-Burns, Sandra ;Seeman, Ego 
Affiliation: Endocrine Centre, Austin Health, University of Melbourne, Melbourne, Australia
Issue Date: 1-Dec-2009
Publication information: Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research; 24(12): 1946-52
Abstract: To identify the racial differences in macro- and microstructure of the distal radius and tibia that may account for the lower fracture rates in Asians than whites, we studied 61 healthy premenopausal Chinese and 111 white women 18-45 yr of age using high-resolution pQCT (HR-pQCT). The Chinese were shorter and leaner. Distal radius total cross-sectional area (CSA) was 14.3% smaller in Chinese because of an 18.0% smaller trabecular area (p < 0.001). Cortical thickness was 8.8% greater in the Chinese, but cortical area was no different. Total volumetric BMD (vBMD) was 10.3% higher in the Chinese because of the 8.8% higher cortical thickness and 2.8% greater cortical density (all p < 0.01). Trabecular vBMD and bone volume/tissue volume (BV/TV) did not differ by race because trabeculae were 7.0% fewer but 10.8% thicker in Chinese than whites (both p < 0.01). Similar results were found at the distal tibia. Lower fracture risk in Chinese women may be partly caused by thicker cortices and trabeculae in a smaller bone-more bone within the bone than in whites.
Gov't Doc #: 19459783
DOI: 10.1359/jbmr.090529
Journal: Journal of Bone and Mineral Research
Type: Journal Article
Subjects: Adolescent
Bone Density
Bone and Bones.anatomy & histology
European Continental Ancestry Group
Middle Aged
Young Adult
Appears in Collections:Journal articles

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