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Title: 11C-PiB PET studies in typical sporadic Creutzfeldt-Jakob disease.
Austin Authors: Villemagne, Victor L ;McLean, Catriona A;Reardon, K;Boyd, A;Lewis, V;Klug, G;Jones, G;Baxendale, D;Masters, Colin L ;Rowe, Christopher C ;Collins, S J
Affiliation: Department of Nuclear Medicine, Centre for PET, Austin Health, 145 Studley Road, Heidelberg, Vic. 3084, Australia
Issue Date: 29-Mar-2009
Publication information: Journal of Neurology, Neurosurgery, and Psychiatry 2009; 80(9): 998-1001
Abstract: Brain amyloid imaging using positron emission tomography (PET) is of increasing importance in the premortem evaluation of dementias, particularly in relation to Alzheimer disease (AD). The purpose of this study was to explore the premortem diagnostic utility of (11)C-PiB PET in sporadic Creutzfeldt-Jakob disease (CJD).Two patients, 72 and 59 years old, underwent evaluation for rapidly progressive cognitive decline, dying after illness durations of 5 and 7 months, respectively. As part of their comprehensive assessment, (18)F-FDG PET and (11)C-PiB PET studies were performed approximately 2-4 weeks prior to death, and the brain regional distributions compared with those from cohorts of healthy controls (HC) and AD patients.Routine investigations, including brain MRI scans, revealed changes typical of sporadic CJD, with the diagnosis confirmed at autopsy in both patients. The (18)F-FDG PET showed global hypometabolism in one patient and thalamic and frontal hypometabolism with unexpected hypermetabolism in the dentate nuclei of the cerebellum in the other. Neither patient displayed cerebral cortical (11)C-PiB PET retention above the levels observed in HC.No grey-matter (11)C-PiB retention was observed in two pathologically confirmed cases of typical sporadic CJD. We speculate that low PrP plaque density and small plaque size, as well as a relatively low affinity of the radioligand, explain the absence of (11)C-PiB retention. More studies to validate this hypothesis are warranted.
DOI: 10.1136/jnnp.2008.171496
Journal: Journal of neurology, neurosurgery, and psychiatry
Type: Journal Article
Subjects: Aged
Benzothiazoles.diagnostic use
Brain Chemistry.physiology
Creutzfeldt-Jakob Syndrome.metabolism.pathology.radionuclide imaging
Fatal Outcome
Fluorodeoxyglucose F18.diagnostic use
Magnetic Resonance Imaging
Middle Aged
Positron-Emission Tomography
Radiopharmaceuticals.diagnostic use
Appears in Collections:Journal articles

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