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Title: A neurologist's guide to genome-wide association studies.
Austin Authors: Mullen, Saul A ;Crompton, Douglas E;Carney, Patrick W ;Helbig, Ingo;Berkovic, Samuel F 
Affiliation: Epilepsy Research Centre and Department of Medicine (Neurology), University of Melbourne, Austin Health, 145 Studley Rd., Heidelberg, Victoria 3084, Australia
Issue Date: 10-Feb-2009
Publication information: Neurology; 72(6): 558-65
Abstract: Genome-wide association studies are utilized for gene discovery in common diseases. Genotypes of large groups of unrelated patients are compared to controls. This has become feasible due to the recent technical advances in genomics and convincing positive results are now regularly being published. This review is an accessible introduction to the genetic and technical knowledge needed to interpret such studies. Genome-wide association studies are being applied to many neurologic diseases. Here we use idiopathic generalized epilepsy as an example to highlight the phenotyping, sample size, and statistical issues that must be addressed in such studies. These studies are likely to transform our understanding of complex neurologic diseases in the next few years.
Gov't Doc #: 19204266
DOI: 10.1212/
Type: Journal Article
Subjects: Chromosome Mapping.methods
Clinical Trials as Topic
Genetic Predisposition to Disease.epidemiology.genetics
Genome-Wide Association Study.methods
Nervous System Diseases.epidemiology.genetics
Polymorphism, Single Nucleotide.genetics
Appears in Collections:Journal articles

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