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Title: Positron emission tomography changes management, improves prognostic stratification and is superior to gallium scintigraphy in patients with low-grade lymphoma: results of a multicentre prospective study.
Austin Authors: Scott, Andrew M ;Gunawardana, Dishan H;Wong, Joseph;Kirkwood, Ian;Hicks, Rodney J;Ho Shon, Ivan;Ramshaw, Jayne E;Robins, Peter
Affiliation: Centre for PET, Austin Hospital, Studley Rd, Heidelberg, Melbourne, Victoria 3084, Australia
Issue Date: 18-Oct-2008
Publication information: European Journal of Nuclear Medicine and Molecular Imaging 2008; 36(3): 347-53
Abstract: Positron emission tomography (PET) was evaluated in low-grade non-Hodgkin lymphoma (NHL) to determine its impact on staging and management and to compare PET and gallium scans.PET resulted in management plan changes in 74 patients with untreated low-grade NHL stages I to III. Patient outcomes to 12 months were documented.PET identified additional lesions in 50% of patients, led to a change in stage in 32%, and had a significant impact on management in 34%. Inferior progression-free survival was noted in patients with additional lesions detected by PET (p=0.001) and in the 28% of patients upstaged by PET to stage III or IV (p=0.024). In a subset of 16 patients undergoing both PET and gallium scans, PET was found to be superior.PET has a major role in the management of low-grade NHL in addition to its proven role in aggressive lymphoma.
Gov't Doc #: 18931840
DOI: 10.1007/s00259-008-0958-z
Journal: European journal of nuclear medicine and molecular imaging
Type: Journal Article
Subjects: Disease-Free Survival
Fluorine Radioisotopes.diagnostic use
Fluorodeoxyglucose F18.diagnostic use
Gallium Radioisotopes.diagnostic use
Lymphoma, Non-Hodgkin.pathology.radiography.radionuclide imaging
Neoplasm Staging.methods
Positron-Emission Tomography
Prospective Studies
Radiopharmaceuticals.diagnostic use
Tomography, X-Ray Computed
Appears in Collections:Journal articles

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