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Title: | Positron emission tomography changes management, improves prognostic stratification and is superior to gallium scintigraphy in patients with low-grade lymphoma: results of a multicentre prospective study. | Austin Authors: | Scott, Andrew M ;Gunawardana, Dishan H;Wong, Joseph;Kirkwood, Ian;Hicks, Rodney J;Ho Shon, Ivan;Ramshaw, Jayne E;Robins, Peter | Affiliation: | Centre for PET, Austin Hospital, Studley Rd, Heidelberg, Melbourne, Victoria 3084, Australia | Issue Date: | 18-Oct-2008 | Publication information: | European Journal of Nuclear Medicine and Molecular Imaging 2008; 36(3): 347-53 | Abstract: | Positron emission tomography (PET) was evaluated in low-grade non-Hodgkin lymphoma (NHL) to determine its impact on staging and management and to compare PET and gallium scans.PET resulted in management plan changes in 74 patients with untreated low-grade NHL stages I to III. Patient outcomes to 12 months were documented.PET identified additional lesions in 50% of patients, led to a change in stage in 32%, and had a significant impact on management in 34%. Inferior progression-free survival was noted in patients with additional lesions detected by PET (p=0.001) and in the 28% of patients upstaged by PET to stage III or IV (p=0.024). In a subset of 16 patients undergoing both PET and gallium scans, PET was found to be superior.PET has a major role in the management of low-grade NHL in addition to its proven role in aggressive lymphoma. | Gov't Doc #: | 18931840 | URI: | http://ahro.austin.org.au/austinjspui/handle/1/10695 | DOI: | 10.1007/s00259-008-0958-z | Journal: | European journal of nuclear medicine and molecular imaging | URL: | https://pubmed.ncbi.nlm.nih.gov/18931840 | Type: | Journal Article | Subjects: | Disease-Free Survival Fluorine Radioisotopes.diagnostic use Fluorodeoxyglucose F18.diagnostic use Gallium Radioisotopes.diagnostic use Humans Lymphoma, Non-Hodgkin.pathology.radiography.radionuclide imaging Neoplasm Staging.methods Positron-Emission Tomography Prognosis Prospective Studies Radiopharmaceuticals.diagnostic use Tomography, X-Ray Computed |
Appears in Collections: | Journal articles |
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