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Title: | Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice. | Austin Authors: | Davey, Rachel A;Turner, Andrew G;McManus, Julie F;Chiu, W S Maria;Tjahyono, Francisca;Moore, Alison J;Atkins, Gerald J;Anderson, Paul H;Ma, Cathy;Glatt, Vaida;MacLean, Helen E;Vincent, Cristina;Bouxsein, Mary L;Morris, Howard A;Findlay, David M;Zajac, Jeffrey D | Affiliation: | Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia | Issue Date: | 1-Aug-2008 | Publication information: | Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research; 23(8): 1182-93 | Abstract: | It is well established that calcitonin is a potent inhibitor of bone resorption; however, a physiological role for calcitonin acting through its cognate receptor, the calcitonin receptor (CTR), has not been identified. Data from previous genetically modified animal models have recognized a possible role for calcitonin and the CTR in controlling bone formation; however, interpretation of these data are complicated, in part because of their mixed genetic background. Therefore, to elucidate the physiological role of the CTR in calcium and bone metabolism, we generated a viable global CTR knockout (KO) mouse model using the Cre/loxP system, in which the CTR is globally deleted by >94% but <100%. Global CTRKOs displayed normal serum ultrafiltrable calcium levels and a mild increase in bone formation in males, showing that the CTR plays a modest physiological role in the regulation of bone and calcium homeostasis in the basal state in mice. Furthermore, the peak in serum total calcium after calcitriol [1,25(OH)(2)D(3)]-induced hypercalcemia was substantially greater in global CTRKOs compared with controls. These data provide strong evidence for a biological role of the CTR in regulating calcium homeostasis in states of calcium stress. | Gov't Doc #: | 18627265 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/10639 | DOI: | 10.1359/jbmr.080310 | Journal: | Journal of Bone and Mineral Research | URL: | https://pubmed.ncbi.nlm.nih.gov/18627265 | Type: | Journal Article | Subjects: | Acid Phosphatase.metabolism Actins.metabolism Animals Calcitonin.blood Calcitriol.pharmacology Calcium.blood Female Femur.anatomy & histology.pathology Gene Deletion Gene Targeting Hypercalcemia.metabolism.prevention & control Integrases.metabolism Isoenzymes.metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Osteoclasts.drug effects.metabolism.pathology Phenotype Receptors, Calcitonin.metabolism |
Appears in Collections: | Journal articles |
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