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Title: Thyrotoxicosis during sunitinib treatment for renal cell carcinoma.
Austin Authors: Grossmann, Mathis ;Premaratne, Erosha ;Desai, Jayesh;Davis, Ian D
Affiliation: Endocrine Unit, Austin Health, Victoria, Australia
Issue Date: 3-Apr-2008
Publication information: Clinical Endocrinology 2008; 69(4): 669-72
Abstract: Sunitinib malate is an oral tyrosine kinase inhibitor used in the treatment of renal cell carcinoma (RCC) and gastrointestinal stromal tumours. Hypothyroidism has been observed in patients treated with sunitinib, but the mechanism whereby sunitinib induces hypothyroidism is unknown.To describe a series of six patients who developed thyrotoxicosis while on sunitinib for metastatic RCC.The study was conducted at Austin Health, a tertiary teaching hospital in Melbourne, Australia.Two patients developed severe thyrotoxicosis within 10 weeks after commencing sunitinib. In contrast, in the four patients who presented with later onset (16-30 weeks) thyrotoxicosis, the thyrotoxicosis was relatively mild, self-limiting and rapidly progressed to hypothyroidism. These patients experienced recurrent episodes of thyrotoxicosis in temporal relation to their cyclical sunitinib treatment. One patient had cytological evidence of lymphocytic thyroiditis.These findings suggest that sunitinib-induced hypothyroidism may be a consequence of preceding thyroiditis with associated transient thyrotoxicosis. As predictive factors are currently unknown, we suggest regular monitoring of thyroid function in all patients commenced on sunitinib. Clinicians treating patients with sunitinib or other similar kinase inhibitors should to be alerted to thyroid dysfunction as a potential toxicity of these agents.
Gov't Doc #: 18394019
DOI: 10.1111/j.1365-2265.2008.03253.x
Journal: Clinical Endocrinology
Type: Journal Article
Subjects: Adult
Antineoplastic Agents.adverse effects.therapeutic use
Carcinoma, Renal Cell.blood.drug therapy
Indoles.adverse effects.therapeutic use
Kidney Neoplasms.blood.drug therapy
Middle Aged
Pyrroles.adverse effects.therapeutic use
Thyrotoxicosis.blood.chemically induced.diagnosis
Appears in Collections:Journal articles

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