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Title: The rate of alveolar-capillary uptake of sevoflurane and nitrous oxide following anaesthetic induction.
Austin Authors: Peyton, Philip J ;Fortuin, M;Robinson, Gavin J B;Stuart-Andrews, C;Pierce, Robert J;Thompson, Bruce R
Affiliation: Department of Anaesthesia, Austin Hospital, Melborne, Australia
Issue Date: 1-Apr-2008
Publication information: Anaesthesia; 63(4): 358-63
Abstract: The rate of anaesthetic gas uptake from the breathing system has been extensively measured, but this does not reflect the true rate of early gas uptake by pulmonary blood, which drives inhalational induction of anaesthesia. In eight patients undergoing coronary bypass surgery, we measured the rate of alveolar-capillary uptake of anaesthetic gases up to 30 min following introduction of 0.5% sevoflurane and 33% nitrous oxide using the reverse Fick method, in which blood partial pressures were measured using a headspace equilibration technique. Simultaneous measurements of gas uptake from the breathing system were made by indirect calorimetry. Measured rates of sevoflurane and nitrous oxide uptake from the breathing system agreed well with previously described formulae when adjusted for inspired concentration. The time course of alveolar-capillary gas uptake followed a characteristic rising curve peaking at 3-4 min and then exponentially declining, and for nitrous oxide was significantly higher than previously estimated.
Gov't Doc #: 18336485
DOI: 10.1111/j.1365-2044.2007.05355.x
Type: Journal Article
Subjects: Aged
Aged, 80 and over
Anesthetics, Combined.pharmacokinetics
Anesthetics, Inhalation.pharmacokinetics
Calorimetry, Indirect
Coronary Artery Bypass
Methyl Ethers.pharmacokinetics
Middle Aged
Models, Biological
Nitrous Oxide.pharmacokinetics
Pulmonary Alveoli.metabolism
Appears in Collections:Journal articles

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