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Title: Review of experimental animal models of acute pancreatitis.
Austin Authors: Su, Kim Hue;Cuthbertson, Christine M;Christophi, Christopher 
Affiliation: Department of Surgery, University of Melbourne, Austin Hospital, Melbourne, Victoria, Australia
Issue Date: 2006
Publication information: Hpb : the Official Journal of the International Hepato Pancreato Biliary Association; 8(4): 264-86
Abstract: The underlying mechanisms involved in the pathogenesis of acute pancreatitis are ill understood. The mortality rate of this disease has not significantly improved over the past few decades. Current treatment options are limited, and predominantly aimed at supportive therapy. A key feature of severe acute pancreatitis is the presence of extensive tissue necrosis with both local and systemic manifestations of inflammatory response syndromes. A better understanding of the underlying pathophysiology of severe acute pancreatitis may lead to more targeted therapeutic options, potentially leading to improved survival. Animal models of acute pancreatitis are therefore an essential investigative tool for these aims to be achieved. This review discusses the suitability of recent non-invasive models of acute pancreatitis such as hormone-induced, alcohol-induced, immune-mediated, diet-induced, gene knockout and L-arginine; and invasive models including closed duodenal loop, antegrade pancreatic duct perfusion, biliopancreatic duct injection, combination of secretory hyperstimulation with minimal intraductal bile acid exposure, vascular-induced, ischaemia/reperfusion and duct ligation.
Gov't Doc #: 18333137
DOI: 10.1080/13651820500467358
Journal: HPB : the official journal of the International Hepato Pancreato Biliary Association
Type: Journal Article
Appears in Collections:Journal articles

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