Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10551
Title: Serial measurements of cystatin C are more accurate than creatinine-based methods in detecting declining renal function in type 1 diabetes.
Austin Authors: Premaratne, Erosha ;MacIsaac, Richard J;Finch, Sue;Panagiotopoulos, Sianna ;Ekinci, Elif I ;Jerums, George 
Affiliation: Endocrine Centre, Austin Health, University of Melbourne, Melbourne, Australia
Issue Date: 4-Mar-2008
Publication information: Diabetes Care 2008; 31(5): 971-3
Abstract: Cystatin C-and creatinine-based methods were compared with (99m)-technetium-diethylene-triamine-penta-acetic acid ((99m)Tc-DTPA) plasma clearance (isotopic glomerular filtration rate [iGFR]) for detecting declining renal function.Glomerular filtration rate (GFR) was monitored over a mean of 10.1 years in 85 subjects with type 1 diabetes (with an average of 5.6 measurements per individual). Baseline mean +/- SD iGFR of the cohort was 106.1 +/- 2.6 ml/min per 1.73 m(2). The rates of decline in GFR (DeltaGFR) were derived using linear regression.In 19 of 85 subjects with declining renal function (i.e., DeltaiGFR >3.3 ml/min per 1.73 m(2) per year), DeltaGFR (ml/min per 1.73 m(2) per year) was 6.5 by iGFR, 4.2 by 10(4)/creatinine, 3.6 by Cockcroft-Gault formula, 3.4 by the Modification of Diet in Renal Disease (MDRD)-6 equation, and 3.5 by the MDRD-4 variable equation (P < 0.01 vs. iGFR). In comparison, DeltaGFR was 6.1 using the formula Cys-GFR = (86.7/cystatin C concentration) - 4.2 (not significant).Cystatin C was more accurate in detecting decline in renal function than creatinine-based methods in this population of subjects with type 1 diabetes and a normal mean baseline GFR.
Gov't Doc #: 18319326
URI: https://ahro.austin.org.au/austinjspui/handle/1/10551
DOI: 10.2337/dc07-1588
ORCID: 0000-0002-0845-0001
Journal: Diabetes Care
URL: https://pubmed.ncbi.nlm.nih.gov/18319326
Type: Journal Article
Subjects: Adolescent
Adult
Aged
Asian Continental Ancestry Group
Australia
Creatinine.blood
Cystatin C
Cystatins.blood
Diabetes Mellitus, Type 1.blood.complications.physiopathology
Diabetic Nephropathies.blood.diagnosis.physiopathology
European Continental Ancestry Group
Female
Glomerular Filtration Rate
Humans
Kidney Function Tests
Male
Middle Aged
Reproducibility of Results
Appears in Collections:Journal articles

Show full item record

Page view(s)

30
checked on Nov 4, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.