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Title: Low testosterone levels are common and associated with insulin resistance in men with diabetes.
Austin Authors: Grossmann, Mathis ;Thomas, Merlin C;Panagiotopoulos, Sianna ;Sharpe, Ken;Macisaac, Richard J;Clarke, Sophie;Zajac, Jeffrey D ;Jerums, George 
Affiliation: Department of Endocrinology and Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 4-Mar-2008
Publication information: The Journal of Clinical Endocrinology and Metabolism 2008; 93(5): 1834-40
Abstract: Low testosterone levels are common in men with type 2 diabetes and may be associated with insulin resistance.We investigated prevalence of testosterone deficiency and the relationship between testosterone and insulin resistance in a large cohort of men with type 2 and type 1 diabetes.The study was a cross-sectional survey of 580 men with type 2 diabetes and 69 men with type 1 diabetes. A subgroup of 262 men with type 2 diabetes was then reassessed after a median of 6 months.Forty-three percent of men with type 2 diabetes had a reduced total testosterone, and 57% had a reduced calculated free testosterone. Only 7% of men with type 1 diabetes had low total testosterone. By contrast, 20.3% of men with type 1 diabetes had low calculated free testosterone, similar to that observed in type 2 diabetes (age-body mass index adjusted odds ratio = 1.4; 95% confidence interval = 0.7-2.9). Low testosterone levels were independently associated with insulin resistance in men with type 1 diabetes as well as type 2 diabetes. Serial measurements also revealed an inverse relationship between changes in testosterone levels and insulin resistance.Testosterone deficiency is common in men with diabetes, regardless of the type. Testosterone levels are partly influenced by insulin resistance, which may represent an important avenue for intervention, whereas the utility of testosterone replacement remains to be established in prospective trials.
Gov't Doc #: 18319314
DOI: 10.1210/jc.2007-2177
ORCID: 0000-0002-0845-0001
Type: Journal Article
Subjects: Adult
Cross-Sectional Studies
Diabetes Mellitus.blood
Diabetes Mellitus, Type 1.blood
Diabetes Mellitus, Type 2.blood
Insulin Resistance
Middle Aged
Sex Hormone-Binding Globulin.analysis
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