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Title: Comparison of sequential cyproterone acetate/estrogen versus spironolactone/oral contraceptive in the treatment of hirsutism.
Austin Authors: O'Brien, R C;Cooper, Mark E;Murray, R M;Seeman, Ego ;Thomas, A K;Jerums, George 
Affiliation: Department of Endocrinology, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-May-1991
Publication information: The Journal of Clinical Endocrinology and Metabolism; 72(5): 1008-13
Abstract: The effects of the antiandrogen drugs cyproterone acetate (CPA) and spironolactone on hair growth and androgen levels were compared in a randomized study of 48 hirsute women. Twenty six subjects completed 6 months of therapy with 100 mg/day CPA and 19 subjects completed 6 months of 100 mg/day spironolactone. All except 10 subjects received concomitant estrogen therapy. Measured objectively, total hair diameter fell by 17.1% with spironolactone (P less than 0.001), and by 16.8% with CPA (P less than 0.001). The diameter of the hair medulla fell by 17.8% with spironolactone (P less than 0.01), and by 31.7% with CPA (P less than 0.001). There was no difference between the drugs in their effect on hair diameter. Plasma testosterone levels also fell significantly with both drugs. As a subjective assessment of treatment efficacy, the frequency with which subjects performed cosmetic measures was recorded. This fell by 38% with spironolactone and by 44.7% with CPA (P less than 0.001 both drugs), and again there was no difference between the drugs. Side effects caused cessation of treatment in one subject taking CPA and two subjects taking spironolactone, and milder side effects were noted in two further subjects from each treatment group. We conclude that spironolactone and CPA, in the dosages used in this study, are effective and well tolerated agents for the treatment of hirsutism, and that neither drug demonstrates a particular advantage over the other.
Gov't Doc #: 1827125
DOI: 10.1210/jcem-72-5-1008
Type: Journal Article
Subjects: Adult
Androgen Antagonists.adverse effects.therapeutic use
Contraceptives, Oral.adverse effects.therapeutic use
Cyproterone.adverse effects.analogs & derivatives.therapeutic use
Cyproterone Acetate
Drug Therapy, Combination
Estrogens.adverse effects.therapeutic use
Hair.growth & development
Hirsutism.drug therapy
Middle Aged
Prospective Studies
Spironolactone.adverse effects.therapeutic use
Appears in Collections:Journal articles

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