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Title: Liver regeneration and tumor stimulation--a review of cytokine and angiogenic factors.
Austin Authors: Christophi, Christopher ;Harun, Nadia;Fifis, Theodora
Affiliation: Department of Surgery, University of Melbourne, Austin Health, Level 8 Lance Townsend Building, Studley Rd, Heidelberg, Melbourne, Victoria 3084, Australia
Issue Date: 8-Jan-2008
Publication information: Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract 2008; 12(5): 966-80
Abstract: Liver resection for metastatic (colorectal carcinoma) tumors is often followed by a significant incidence of tumor recurrence. Cellular and molecular changes resulting from hepatectomy and the subsequent liver regeneration process may influence the kinetics of tumor growth and contribute to recurrence. Clinical and experimental evidence suggests that factors involved in liver regeneration may also stimulate the growth of occult tumors and the reactivation of dormant micrometastases. An understanding of the underlying changes may enable alternative strategies to minimize tumor recurrence and improve patient survival after hepatectomy.
Gov't Doc #: 18181006
DOI: 10.1007/s11605-007-0459-6
Journal: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
Type: Journal Article
Subjects: Colorectal Neoplasms.pathology
Intercellular Signaling Peptides and Proteins.physiology
Liver Neoplasms.blood supply.physiopathology.secondary
Liver Regeneration.physiology
Neoplasm Metastasis.physiopathology
Neovascularization, Pathologic.physiopathology
Appears in Collections:Journal articles

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