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Title: An open-label study of quetiapine in anorexia nervosa.
Austin Authors: Bosanac, Peter;Kurlender, S;Norman, Trevor R ;Hallam, K;Wesnes, K;Manktelow, T;Burrows, Graham D
Affiliation: Department of Psychiatry, University of Melbourne, and Austin Hospital, Australia
Issue Date: 1-Jun-2007
Publication information: Human Psychopharmacology; 22(4): 223-30
Abstract: Atypical antipsychotics may be beneficial in treating the core psychopathology of anorexia nervosa (AN).An 8 week open-label study of quetiapine was conducted in eight severely ill DSM-IV AN patients consecutively admitted to a specialist eating disorders unit. Participants were assessed by EDE-12, MADRS, YBOCS, SAPS-delusions and CDR neuropsychological battery at baseline, 4 weeks and 8 weeks, and by weekly body mass index (BMI), CGI and extrapyramidal scores. Quetiapine doses ranged from 50 mg to 800 mg per day, according to efficacy and tolerability.Seven participants completed 4 weeks and five participants completed 8 weeks. All participants had clinically significant levels of specific eating disorders psychopathology, and mild to moderately severe depressive symptomatology. Apart from initial mild sedation, no subjects experienced any significant adverse events. Over 4 weeks there was no significant difference in BMI, but a significant difference in the EDE-12 restraint score. There were significant differences on BMI and EDE-12 restraint subscale scores over 8 weeks.A double-blind placebo controlled study is required to further evaluate the therapeutic utility of quetiapine in severely ill AN patients beyond multidisciplinary specialist intervention.
Gov't Doc #: 17487935
DOI: 10.1002/hup.845
Type: Journal Article
Subjects: Adult
Anorexia Nervosa.drug therapy.psychology
Antipsychotic Agents.adverse effects.therapeutic use
Arousal.drug effects
Body Mass Index
Dibenzothiazepines.adverse effects.therapeutic use
Dyskinesia, Drug-Induced.epidemiology
Neuropsychological Tests
Obsessive Behavior.psychology
Psychiatric Status Rating Scales
Reaction Time.drug effects
Weight Gain
Appears in Collections:Journal articles

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