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Title: Genetic polymorphisms in sepsis- and cardiopulmonary bypass-associated acute kidney injury.
Austin Authors: Haase-Fielitz, Anja;Haase, Michael;Bellomo, Rinaldo ;Dragun, Duska
Affiliation: Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 2007
Publication information: Contributions To Nephrology; 156(): 75-91
Abstract: Acute kidney injury (AKI) is a major medical problem in critical illness, and has a separate independent effect on the risk of death. Septic shock and cardiac surgery utilizing cardiopulmonary bypass are the two most common factors contributing to AKI. Clinical predictors and biochemical markers identified for the development of AKI can only explain a part of this individual risk. Another tool to predict the risk of AKI and to improve individualized patient care focuses on the identification of genetic risk factors which might be involved in the development of AKI. However, to date our knowledge on the importance of such genetic polymorphisms in influencing the susceptibility to and severity of AKI remains limited. There is evidence that several genetic polymorphisms accounting for sepsis- or cardiopulmonary bypass-associated AKI involve genes which participate in the control of inflammatory or vasomotor processes. In this article, we will review current knowledge concerning the role of genetic polymorphism in the pathogenesis of sepsis- and cardiopulmonary bypass-associated AKI and discuss possible areas for future developments and research in this field.
Gov't Doc #: 17464117
DOI: 10.1159/0000102072
Journal: Contributions to nephrology
Type: Journal Article
Subjects: Acute Kidney Injury.etiology.genetics
Apolipoproteins E.genetics
Cardiopulmonary Bypass.adverse effects
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Risk Factors
Severity of Illness Index
Tumor Necrosis Factor-alpha.genetics
Appears in Collections:Journal articles

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