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Title: Effect of adenosine triphosphate-sensitive potassium channel inhibitors on coronary metabolic vasodilation.
Austin Authors: Farouque, Omar ;Meredith, Ian T
Affiliation: Department of Cardiology, Austin Health, Heidelberg, Victoria, 3084, Australia
Issue Date: 1-Feb-2007
Publication information: Trends in Cardiovascular Medicine; 17(2): 63-8
Abstract: The ATP-sensitive potassium (K(ATP)) channel is a distinct type of potassium ion channel that is found in the vascular smooth muscle cells of a variety of mammalian species, including humans. The activity of K(ATP) channels is determined by many factors including cellular ATP and ADP levels, thus providing a link between cellular metabolism and vascular tone through its effects on membrane potential. Experimental studies using inhibitors of K(ATP) channels, such as the sulfonuylurea class of drugs, indicate that these channels modulate coronary vascular tone including the hyperaemia induced by increased myocardial metabolism. This review examines the evidence linking K(ATP) channels to the regulation of coronary vascular tone and the potential clinical implications of pharmacologic therapies that act on K(ATP) channels.
Gov't Doc #: 17292049
DOI: 10.1016/j.tcm.2006.12.003
Type: Journal Article
Subjects: Adenosine Triphosphate.physiology
Coronary Disease.drug therapy.physiopathology
Coronary Vessels.drug effects.physiology.physiopathology
Muscle, Smooth, Vascular.drug effects.physiology
Potassium Channel Blockers.pharmacology
Potassium Channels.physiology
Vasodilation.drug effects.physiology
Appears in Collections:Journal articles

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