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Title: Striatal dopaminergic neurons are lost with Parkinson's disease progression.
Austin Authors: Porritt, Michelle J;Kingsbury, Ann E;Hughes, Andrew J ;Howells, David William
Affiliation: Austin Health, Department of Medicine, University of Melbourne, Victoria, Australia
Issue Date: 1-Dec-2006
Publication information: Movement Disorders : Official Journal of the Movement Disorder Society; 21(12): 2208-11
Abstract: Increased numbers of dopaminergic neurons are described in the striatum of patients with Parkinson's disease. In postmortem striatal tissue from Parkinson's disease patients with short disease duration (< or =8 years), the number of dopaminergic neurons is approximately four times that in patients with long duration (> or =16 years). The data suggest the possibility that the presence of large numbers of these striatal dopaminergic neurons may be harmful and may accelerate the disease process. Alternatively, these neurons may be lost to the disease process.
Gov't Doc #: 17029264
DOI: 10.1002/mds.21129
Journal: Movement disorders : official journal of the Movement Disorder Society
Type: Journal Article
Subjects: Aged
Aged, 80 and over
Cell Death.physiology
Corpus Striatum.pathology
Disease Progression
Parkinson Disease.pathology
Time Factors
Tyrosine 3-Monooxygenase.metabolism
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