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Title: Increase in galanin and neuropeptide Y mRNA in locus coeruleus following acute reserpine treatment.
Austin Authors: Gundlach, Andrew L;Rutherfurd, S D;Louis, William J 
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 2-Aug-1990
Publication information: European Journal of Pharmacology; 184(1): 163-7
Abstract: Galanin and neuropeptide Y are known to coexist with noradrenaline in neurones of the locus coeruleus. Furthermore, reserpine depletes noradrenaline from, and increases the synthesis and activity of the catecholamine-synthesizing enzyme tyrosine hydroxylase in, this nucleus. We have found by in situ hybridization of specific 35S-labelled oligonucleotide probes that a single dose of reserpine (10 mg/kg) induced a significant (70-145%) and long-lasting (up to at least 3 days) increase in the amount of galanin and neuropeptide Y mRNA in the locus coeruleus (along with the characteristic increase in tyrosine hydroxylase mRNA). These results suggest a similar reserpine-sensitive mechanism of galanin, neuropeptide Y and tyrosine hydroxylase gene regulation.
Gov't Doc #: 1698642
Type: Journal Article
Subjects: Animals
Locus Coeruleus.drug effects.metabolism
Neuropeptide Y.genetics
Nucleic Acid Hybridization
RNA, Messenger.metabolism
Rats, Inbred Strains
Appears in Collections:Journal articles

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